glutamate
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Name: glutamate
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Description: An unspecified stereoisomerism form of glutamate which showed age-related changes in the plasma metabolome. (PMID: 18384253)
Overview of age-variations
| Age group comparisons | ||||
|---|---|---|---|---|
| PMID | Age/Age interval, Gender | Value (unit of measurement) | Method | Sample |
| 15708441 | Age 26 ± 1, Gender ⚥ | 9.58 (nM) | H-MRS | motor cortex |
| 15708441 | Age 54 ± 6, Gender ⚥ | 8.34 (nM) | H-MRS | motor cortex |
| 23701591 | Age [54-57], Gender ⚥ (Taiwanese population) | 4.6 (signal intensity) | HNMR | urine |
| 23701591 | Age [79-91], Gender ⚥ (Taiwanese population) | 5.21 (signal intensity) | HNMR | urine |
| 27374292 | Age [25–35] (median=32), Gender ♀ (Japanese) | 0.748115 (average level of metabolite) | UHPLC-MS/MS Positive mode | serum |
| 27374292 | Age [55–65] (median=60), Gender ♀ (Japanese) | 1.089607 (average level of metabolite) | UHPLC-MS/MS Positive mode | serum |
| 27374292 | Age [25–35] (median=32), Gender ♂ (Japanese) | 0.949468 (average level of metabolite) | UHPLC-MS/MS Positive mode | serum |
| 27374292 | Age [55–64] (median=60), Gender ♂ (Japanese) | 1.407679 (average level of metabolite) | UHPLC-MS/MS Positive mode | serum |
| Linear regression | ||||
|---|---|---|---|---|
| PMID | Age/Age interval, Gender | Value (unit of measurement) | Method | Sample |
| 23838602 | Age [17–85], Gender ⚥ | 0.016 (β) | UHPLC/MS/MS | serum and plasma |
| 23838602 | Age [17–85], Gender ⚥ | 1.6 (β) | UHPLC/MS/MS | serum and plasma |
| 23838602 | Age [17–85], Gender ⚥ | 1.45 (β) | UHPLC/MS/MS | serum and plasma |
| 23838602 | Age [17–85], Gender ⚥ | 1.75 (β) | UHPLC/MS/MS | serum and plasma |
| 30659340 | Age [20-70], Gender ⚥ | -0.034 (β) | wbMRSI | occipital gray matter |
| 30659340 | Age [20-70], Gender ⚥ | -0.27 (β) | wbMRSI | parietal white matter |
| log2 ratio/log2(FC) | ||||
|---|---|---|---|---|
| PMID | Age/Age interval, Gender | Value (unit of measurement) | Method | Sample |
Summary
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Chemical Formula:C5H9NO4
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Systematic name:2-aminopentanedioic acid
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SMILES:C(CC(=O)O)C(C(=O)O)N
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InChI:InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)
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InChI Key:WHUUTDBJXJRKMK-UHFFFAOYSA-N
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CAS number:617-65-2
Related resources
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Literature sources:
- Kaiser LG et al., Age-related glutamate and glutamine concentration changes in normal human brain: 1H MR spectroscopy study at 4 T., Neurobiology of aging, 665-72, 2005
- Saito K et al., Gender- and Age-Associated Differences in Serum Metabolite Profiles among Japanese Populations., Biological & pharmaceutical bulletin, 1179-86, 2016
- Swann JR et al., Microbial-mammalian cometabolites dominate the age-associated urinary metabolic phenotype in Taiwanese and American populations., Journal of proteome research, 3166-80, 2013
- Maghsudi H et al., Regional Metabolite Concentrations in Aging Human Brain: Comparison of Short-TE Whole Brain MR Spectroscopic Imaging and Single Voxel Spectroscopy at 3T., Clinical neuroradiology, 251-261, 2020
- Menni C et al., Metabolomic markers reveal novel pathways of ageing and early development in human populations., International journal of epidemiology, 1111-9, 2013
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External links:
Metabolite sources and localization
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Metabolite location:Human organism, Body part, Human body biofluids, Biofluid tissues, Blood, Plasma, Urine, Organ, Brain, Cerebral cortex, Motor cortex, Occipital lobe, Occipital gray matter, Parietal lobe, Parietal white matter, Tissue, Excreta material
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Metabolite source:Homo sapiens, endogenous metabolite
Age-variations
Linear regression
Method: UHPLC/MS/MS
Sample: serum and plasma
β = 0.016
(y = βx + α)
p-value < 0.05
Linear regression
Method: UHPLC/MS/MS
Sample: serum and plasma
β = 1.6
(y = βx + α)
p-value < 0.05
Linear regression
Method: UHPLC/MS/MS
Sample: serum and plasma
β = 1.45
(y = βx + α)
p-value < 0.05
Linear regression
Method: UHPLC/MS/MS
Sample: serum and plasma
β = 1.75
(y = βx + α)
p-value < 0.05
Linear regression
Method: wbMRSI
Sample: occipital gray matter
β = -0.034
(y = βx + α)
p-value < 0.05
Linear regression
Method: wbMRSI
Sample: parietal white matter
β = -0.27
(y = βx + α)
p-value < 0.05