dimethylarginine (SDMA)

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Name: dimethylarginine (SDMA)
Description: Symmetric dimethylarginine (SDMA) is an endogenously produced inhibitor of nitric oxide synthase (EC-Number 1.14.13.39). However, elevated levels of SDMA occur in patients with vascular disease, es... pecially suffering end-stage renal disease. (PMID 12401860). SDMA is an L-arginine derivative having two methyl groups at the Nω- and N'ω-positions. (CHEBI:25682)

Age group comparisons
PMID	Age/Age interval, Gender	Value (unit of measurement)	Method	Sample

Linear regression
PMID	Age/Age interval, Gender	Value (unit of measurement)	Method	Sample
23838602	Age [17–85], Gender ⚥	-0.005 (β)	UHPLC/MS/MS	serum + plasma

log2 ratio/log2(FC)
PMID	Age/Age interval, Gender	Value (unit of measurement)	Method	Sample

Synonym:

N(G1),N(G2)-Dimethylarginine; (2S)-2-amino-5-(N',N''-dimethylcarbamimidamido)pentanoic acid; NG,N'G-dimethylarginine; (S)-2-amino-5-(N',N''-dimethylguanidino)pentanoic acid; N,N'-Dimethylarginine; N3,N4-dimethylarginine;symmetric dimethylarginine; guanidino-N(1),N(2)-dimethylarginine
Chemical Formula:

C8H18N4O2
Exact Mass g/mol:

202.1430000
Systematic name:

N5-(N,N'-dimethylcarbamimidoyl)-L-ornithine;(2S)-2-amino-5-[(N,N'-dimethylcarbamimidoyl)amino]pentanoic acid
SMILES:

CNC(=NC)NCCC[C@@H](C(=O)O)N
InChI:

InChI=1S/C8H18N4O2/c1-10-8(11-2)12-5-3-4-6(9)7(13)14/h6H,3-5,9H2,1-2H3,(H,13,14)(H2,10,11,12)/t6-/m0/s1
InChI Key:

HVPFXCBJHIIJGS-LURJTMIESA-N
CAS number:

30344-00-4

Literature sources:
- Menni C et al., Metabolomic markers reveal novel pathways of ageing and early development in human populations., International journal of epidemiology, 1111-9, 2013
External links:

HMDB PubChem ChEBI

Metabolite location:

Human organism, Body part, Human body biofluids, Biofluid tissues, Blood, Plasma, Serum, Saliva, Urine, Organ, Kidney, Tissue, Excreta material, Feces
Metabolite source:

Homo sapiens, endogenous metabolite

Linear regression

Method: UHPLC/MS/MS

Sample: serum + plasma

PMID: 23838602

β = -0.005 (y = βx + α)

p-value < 0.05