serine

view
  • Name: serine
  • Description: Serine is a non-essential amino acid in humans (synthesized by the body), Serine is present and functionally important in many proteins. With an alcohol group, serine is needed for the metabolism o... f fats, fatty acids, and cell membranes; muscle growth; and a healthy immune system. It also plays a major role in pyrimidine, purine, creatine, and porphyrin biosynthetic pathways. Serine is also found at the active site of the serine protease enzyme class that includes trypsin and chymotrypsin. (NCI Thesaurus:C29613)
Overview of age-variations
Age group comparisons
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
12768504 Age 32.6 ± 4.4 , Gender ♀ 167.0 (μmol/l) LC blood
12768504 Age 48 ± 4.3, Gender ♀ 155.0 (μmol/l) LC blood
12768504 Age 74.7 ± 10, Gender ♀ 129.0 (μmol/l) LC blood
12768504 Age 33.3 ± 3.8, Gender ♂ 131.0 (μmol/l) LC blood
12768504 Age 48.4 ± 6, Gender ♂ 132.0 (μmol/l) LC blood
12768504 Age 75.9 ± 9.3, Gender ♂ 127.0 (μmol/l) LC blood
Linear regression
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
23838602 Age [17–85], Gender ⚥ 0.007 (β) UHPLC/MS/MS serum and plasma
23838602 Age [17–85], Gender ⚥ -2.17 (β) UHPLC/MS/MS serum and plasma
23838602 Age [17–85], Gender ⚥ -2.04 (β) UHPLC/MS/MS serum and plasma
23838602 Age [17–85], Gender ⚥ -1.88 (β) UHPLC/MS/MS serum and plasma
30841604 Age [25-74], Gender ♀ 0.04 (β) indirect potentiometry serum
30841604 Age [45-80], Gender ♀ 0.01 (β) FIA-ESI-MS/MS serum
log2 ratio/log2(FC)
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
Summary
  • Synonym:
    2-amino-3-hydroxypropionic acid;3-hydroxyalanine; ; L Serine
  • Chemical Formula:
    C3H7NO3
  • Systematic name:
    (2S)-2-amino-3-hydroxypropanoic acid
  • SMILES:
    C(C(C(=O)O)N)O
  • InChI:
    InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
  • InChI Key:
    MTCFGRXMJLQNBG-REOHCLBHSA-N
  • CAS number:
    56-45-1
Related resources
Metabolite sources and localization
  • Metabolite location:
    Human organism, Body part, Extracellular, Human body biofluids, Biofluid tissues, Blood, Cerebrospinal fluid, Saliva, Sweat, Urine, Organ, Prostate, Tissue, All tissues, Cellular (general class), Subcellular, Cytoplasm, Mitochondria, Peroxisome, Excreta material, Feces
  • Metabolite source:
    Homo sapiens, endogenous metabolite
Age-variations
Age group comparisons
Method: LC
Sample: blood
PubMed PMID: 12768504
Linear regression
Method: UHPLC/MS/MS
Sample: serum and plasma
PubMed PMID: 23838602
β = 0.007 (y = βx + α)
p-value < 0.05
Linear regression
Method: UHPLC/MS/MS
Sample: serum and plasma
PubMed PMID: 23838602
β = -2.17 (y = βx + α)
p-value < 0.05
Linear regression
Method: UHPLC/MS/MS
Sample: serum and plasma
PubMed PMID: 23838602
β = -2.04 (y = βx + α)
p-value < 0.05
Linear regression
Method: UHPLC/MS/MS
Sample: serum and plasma
PubMed PMID: 23838602
β = -1.88 (y = βx + α)
p-value < 0.05
Linear regression
Method: indirect potentiometry
Sample: serum
PubMed PMID: 30841604
β = 0.04 (y = βx + α)
p-value < 0.05
Linear regression
Method: FIA-ESI-MS/MS
Sample: serum
PubMed PMID: 30841604
β = 0.01 (y = βx + α)
p-value < 0.05
Search the database by metabolite name or synonym