lactate

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  • Name: lactate
  • Description: An unspecified stereoisomer of lactate. A hydroxy monocarboxylic acid anion that is the conjugate base of rac-lactic acid, arising from deprotonation of the carboxyl group. It has a role as a human... metabolite and an Escherichia coli metabolite. It derives from a propionate. Lactate, or 2-hydroxypropanoate, was discovered in 1780 by a Swedish chemist, Scheele, who isolated it from sour milk. It is the simplest hydroxycarboxylate and exists as 2 stereoisomers. Lactate has a pKa of 3.86 and dissociates freely at physiological pH, yielding a lactate ion:lactic acid ratio of 3000:1. (CHEBI:24996)
Overview of age-variations
Age group comparisons
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
18384253 Age 24.5 ± 3, Gender ⚥ 0.73 (mean value of the compound area) LC-MS; GC-MS plasma
18384253 Age 40.8 ± 5.6, Gender ⚥ 1.05 (mean value of the compound area) LC-MS; GC-MS plasma
18384253 Age 55.6 ± 3.7, Gender ⚥ 1.23 (mean value of the compound area) LC-MS; GC-MS plasma
17474139 Age 36.6 ± 5.5, Gender ⚥ 37.3 (mmol/mol ) H-NMR urine
17474139 Age 54.5 ± 7.6, Gender ⚥ 39.5 (mmol/mol ) H-NMR urine
23701591 Age [34-39], Gender ⚥ (American population) 2.45 (signal intensity) HNMR urine
23701591 Age [72-84], Gender ⚥ (American population) 1.98 (signal intensity) HNMR urine
12535825 Age 26 ± 5, Gender ♂ 0.68 (μmol/ml) radioimunoassay plasma
12535825 Age 67 ± 5, Gender ♂ 0.92 (μmol/ml) radioimunoassay plasma
27374292 Age [25–35] (median=32), Gender ♂ (Japanese) 0.951886 (average level of metabolite) UHPLC-MS/MS HILIC serum
27374292 Age [55–64 (median=60), Gender ♂ (Japanese) 1.20589 (average level of metabolite) UHPLC-MS/MS HILIC serum
Linear regression
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
23838602 Age [17–85], Gender ⚥ 0.008 (β) UPLC-MS/MS; GC-MS serum, plasma
log2 ratio/log2(FC)
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
Summary
  • Synonym:
    lactate anion; 2-hydroxypropanoic acid, ion(1−);2-hydroxypropionate
  • Chemical Formula:
    C3H5O3-
  • Exact Mass g/mol:
    89.0240000
  • Systematic name:
    2-hydroxypropanoate
  • SMILES:
    CC(C(=O)[O-])O
  • InChI:
    InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1
  • InChI Key:
    JVTAAEKCZFNVCJ-UHFFFAOYSA-M
  • CAS number:
    113-21-3
Related resources
Metabolite sources and localization
  • Metabolite location:
    Human organism, Body part, Human body biofluids, Biofluid tissues, Blood, Plasma, Serum, Urine, Tissue, Excreta material
  • Metabolite source:
    Homo sapiens, endogenous metabolite
Age-variations
Age group comparisons
Method: LC-MS; GC-MS
Sample: plasma
PubMed PMID: 18384253
Age group comparisons
Method: H-NMR
Sample: urine
PubMed PMID: 17474139
Age group comparisons
Method: HNMR
Sample: urine
PubMed PMID: 23701591
Age group comparisons
Method: radioimunoassay
Sample: plasma
PubMed PMID: 12535825
Age group comparisons
Method: UHPLC-MS/MS HILIC
Sample: serum
PubMed PMID: 27374292
Linear regression
Method: UPLC-MS/MS; GC-MS
Sample: serum; plasma
PubMed PMID: 23838602
β = 0.008 (y = βx + α)
p-value < 0.05
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