D-threitol

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  • Name: D-threitol
  • Description: Threitol is a four-carbon sugar alcohol with the molecular formula C4H10O4. It is primarily used as an intermediate in the chemical synthesis of other compounds. It is the diastereomer of erythrito... l. In living things, threitol is found in the edible fungus Armillaria mellea. D-Threitol can be regarded as the main end product of D-xylose metabolism in humans. Threitol is a C4-polyol (tetritol); the total C4-polyol concentration of threitol decreases with age. Several inborn errors of metabolism with abnormal polyol concentrations in body fluids are known to date (such as pentosuria and galactosemia). Most of these defects can be diagnosed by the assessment of urinary concentrations of polyols. Several studies have revealed that urinary levels of some polyols may vary in diseases associated with carbohydrate metabolism derangements such as diabetes mellitus and uremia. The abnormal occurrence of various polyols in diseases with a specific enzyme deficiency such as pentosuria and galactosemia has also been reported (PMID: 908147 , PMID:16435188 , PMID:14988808 , Analytical Sciences (1990), 6(5), 657-66.))
Overview of age-variations
Age group comparisons
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
27374292 Age [25–35] (median=32), Gender ♀ (Japanese) 0.792172 (average level of metabolite) GC/MS serum
27374292 Age [55–65] (median=60), Gender ♀ (Japanese) 1.194275 (average level of metabolite) GC/MS serum
27374292 Age [55–64] (median=60), Gender ♂ (Japanese) 1.515351 (average level of metabolite) GC/MS serum
27374292 Age [25–35] (median=32), Gender ♂ (Japanese) 0.925167 (average level of metabolite) GC/MS serum
Linear regression
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
23838602 Age [17–85], Gender ⚥ 0.025 (β) UPLC-MS/MS; GC-MS serum, plasma
log2 ratio/log2(FC)
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
Summary
  • Synonym:
    D-threo-tetritol
  • Chemical Formula:
    C4H10O4
  • Exact Mass g/mol:
    122.0580000
  • Systematic name:
    (2R,3R)-butane-1,2,3,4-tetrol
  • SMILES:
    C([C@H]([C@@H](CO)O)O)O
  • InChI:
    InChI=1S/C4H10O4/c5-1-3(7)4(8)2-6/h3-8H,1-2H2/t3-,4-/m1/s1
  • InChI Key:
    UNXHWFMMPAWVPI-QWWZWVQMSA-N
  • CAS number:
    2418-52-2
Related resources
Metabolite sources and localization
  • Metabolite location:
    Human organism, Body part, Human body biofluids, Biofluid tissues, Blood, Plasma, Serum, Cerebrospinal fluid, Urine, Tissue, Excreta material, Feces
  • Metabolite source:
    Homo sapiens, endogenous metabolite
Age-variations
Age group comparisons
Method: GC/MS
Sample: serum
PubMed PMID: 27374292
Age group comparisons
Method: GC/MS
Sample: serum
PubMed PMID: 27374292
Linear regression
Method: UPLC-MS/MS; GC-MS
Sample: serum; plasma
PubMed PMID: 23838602
β = 0.025 (y = βx + α)
p-value < 0.05
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