alpha-ketoglutarate

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  • Name: alpha-ketoglutarate
  • Description: Alpha-ketoglutarate (AKG) is a key molecule in the Krebs cycle determining the overall rate of the citric acid cycle of the organism. It is a nitrogen scavenger and a source of glutamate and glutam... ine that stimulates protein synthesis and inhibits protein degradation in muscles. AKG as a precursor of glutamate and glutamine is a central metabolic fuel for cells of the gastrointestinal tract as well. AKG can decrease protein catabolism and increase protein synthesis to enhance bone tissue formation in the skeletal muscles and can be used in clinical applications. (PMID: 26759695)
Overview of age-variations
Age group comparisons
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
27374292 Age [25–35] (median=32), Gender ♂ (Japanese) 0.847972 (average level of metabolite) UHPLC-MS/MS HILIC serum
27374292 Age [55–64 (median=60), Gender ♂ (Japanese) 1.2 (average level of metabolite) UHPLC-MS/MS HILIC serum
Linear regression
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
23838602 Age [17–85], Gender ⚥ 0.011 (β) UPLC-MS/MS; GC-MS serum, plasma
log2 ratio/log2(FC)
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
Summary
  • Synonym:
    2-oxoglutarate(2−); 2-ketoglutarate; 2-oxoglutarate
  • Chemical Formula:
    C5H4O5-2
  • Exact Mass g/mol:
    144.0060000
  • Systematic name:
    pentanedioic acid, 2-oxo-, ion(2-);2-oxopentanedioate
  • SMILES:
    C(CC(=O)[O-])C(=O)C(=O)[O-]
  • InChI:
    InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2
  • InChI Key:
    KPGXRSRHYNQIFN-UHFFFAOYSA-L
  • CAS number:
    64-15-3
Related resources
Metabolite sources and localization
  • Metabolite location:
    Human organism, Body part, Human body biofluids, Biofluid tissues, Blood, Plasma, Serum, Tissue
  • Metabolite source:
    Homo sapiens, endogenous metabolite
Age-variations
Age group comparisons
Method: UHPLC-MS/MS HILIC
Sample: serum
PubMed PMID: 27374292
Linear regression
Method: UPLC-MS/MS; GC-MS
Sample: serum; plasma
PubMed PMID: 23838602
β = 0.011 (y = βx + α)
p-value < 0.05
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