decanoylcarnitine

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Name: decanoylcarnitine
Description: Decanoylcarnitine is a member of the class of compounds known as acylcarnitines. Acylcarnitines are organic compounds containing a fatty acid with the carboxylic acid attached to carnitine through ... an ester bond. Thus, decanoylcarnitine is considered to be a fatty ester lipid molecule. Decanoylcarnitine is practically insoluble (in water) and a weakly acidic compound (based on its pKa). Decanoylcarnitine can be found in blood, feces, and urine. Within the cell, decanoylcarnitine is primarily located in the membrane. It can also be found in the extracellular space. Acylcarnitines are useful in the diagnosis of genetic disorders such as fatty acid oxidation disorders and differentiation between biochemical phenotypes of medium-chain acyl-CoA dehydrogenase (MCAD) deficiency disorders (PMID: 12385891). Moreover, decanoylcarnitine is found to be associated with very long chain acyl-CoA dehydrogenase (VLAD) deficiency, glutaric aciduria II, and celiac disease, which are inborn errors of metabolism. (HMDB0000651)

Age group comparisons
PMID	Age/Age interval, Gender	Value (unit of measurement)	Method	Sample
30113646	Age 44.6 ± 14, Gender ♀ (Dutch)	0.19 (μmol/L)	ESI-MS/MS	plasma
30113646	Age 44.6 ± 13, Gender ♀ (South-Asian Surinamese)	0.17 (μmol/L)	ESI-MS/MS	plasma
30113646	Age 44.6 ± 14, Gender ♀ (Dutch)	111.2 (% (percentage of metabolite concentration compared with baseline (100%) per 10 year increment in age; analyses were adjusted for BMI))	ESI-MS/MS	plasma
30113646	Age 44.6 ± 13, Gender ♀ (South-Asian Surinamese)	109.8 (% (percentage of metabolite concentration compared with baseline (100%) per 10 year increment in age; analyses were adjusted for BMI))	ESI-MS/MS	plasma

Linear regression
PMID	Age/Age interval, Gender	Value (unit of measurement)	Method	Sample
23838602	Age [17–85], Gender ⚥	0.014 (β)	UPLC-MS/MS; GC-MS	serum, plasma

log2 ratio/log2(FC)
PMID	Age/Age interval, Gender	Value (unit of measurement)	Method	Sample

Synonym:

O-decanoylcarnitine
Chemical Formula:

C17H31NO4
Exact Mass g/mol:

315.2410000
Systematic name:

3-decanoyloxy-4-(trimethylazaniumyl)butanoate
SMILES:

CCCCCCCCCC(=O)OC(CC(=O)[O-])C[N+](C)(C)C
InChI:

InChI=1S/C17H33NO4/c1-5-6-7-8-9-10-11-12-17(21)22-15(13-16(19)20)14-18(2,3)4/h15H,5-14H2,1-4H3
InChI Key:

OQWOHRPOYAVIOK-UHFFFAOYSA-N
CAS number:

1492-27-9

Metabolite location:

Human organism, Body part, Human body biofluids, Biofluid tissues, Blood, Plasma, Serum, Urine, Tissue, Cellular (general class), Subcellular, Cell membrane, Cytoplasm, Excreta material, Feces
Metabolite source:

Homo sapiens, endogenous metabolite

Age group comparisons

Method: ESI-MS/MS

Sample: plasma

PMID: 30113646

Age group comparisons

Method: ESI-MS/MS

Sample: plasma

PMID: 30113646

Linear regression

Method: UPLC-MS/MS; GC-MS

Sample: serum; plasma

PMID: 23838602

β = 0.014 (y = βx + α)

p-value < 0.05