3-methylglutarylcarnitine (2)

view
  • Name: 3-methylglutarylcarnitine (2)
  • Description: 3-methylglutarylcarnitine is a diagnostic metabolite of 3-hydroxy-3-methylglutaryl-coenzyme A lyase deficiency. It is also identified in the urine of patients with Reye-like syndrome (PMID:3958190,... PMID:10927963). It is an O-methylglutarylcarnitine compound having 3-methylglutaryl as the acyl substituent. It has a role as a metabolite. (CHEBI:70857)
Overview of age-variations
Age group comparisons
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
27374292 Age [25–35] (median=32), Gender ♀ (Japanese) 0.706542 (average level of metabolite) UHPLC-MS/MS Positive mode serum
27374292 Age [55–65] (median=60), Gender ♀ (Japanese) 1.510523 (average level of metabolite) UHPLC-MS/MS Positive mode serum
Linear regression
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
log2 ratio/log2(FC)
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
Summary
  • Synonym:
    O-3-methylglutarylcarnitine; 3-methylglutaroylcarnitine
  • Chemical Formula:
    C13H23NO6
  • Systematic name:
    3-(4-carboxy-3-methylbutanoyl)oxy-4-(trimethylazaniumyl)butanoate
  • SMILES:
    CC(CC(=O)O)CC(=O)OC(CC(=O)[O-])C[N+](C)(C)C
  • InChI:
    InChI=1S/C13H23NO6/c1-9(5-11(15)16)6-13(19)20-10(7-12(17)18)8-14(2,3)4/h9-10H,5-8H2,1-4H3,(H-,15,16,17,18)
  • InChI Key:
    HFCPFJNSBPQJDP-UHFFFAOYSA-N
Related resources
Metabolite sources and localization
  • Metabolite location:
    Human organism, Body part, Extracellular, Human body biofluids, Biofluid tissues, Blood, Serum, Saliva, Urine, Tissue, Cellular (general class), Subcellular, Cell membrane, Cytoplasm, Excreta material
  • Metabolite source:
    Homo sapiens, endogenous metabolite
Age-variations
Age group comparisons
Method: UHPLC-MS/MS Positive mode
Sample: serum
PubMed PMID: 27374292
Search the database by metabolite name or synonym