gamma-glutamylglutamine

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  • Name: gamma-glutamylglutamine
  • Description: N2-gamma-Glutamylglutamine is a dipeptide obtained from condensation of the gamma-carboxyl group of glutamic acid with the α-amino group of glutamine. Some dipeptides are known to have physiologica... l or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. It has a role as a human metabolite. It derives from L-glutamic acid and L-glutamine. It is a conjugate acid of a gamma-Glu-Gln(1-). (CHEBI:73707)
Overview of age-variations
Age group comparisons
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
27374292 Age [25–35] (median=32), Gender ♀ (Japanese) 0.836901 (average level of metabolite) UHPLC-MS/MS Positive mode serum
27374292 Age [55–65] (median=60), Gender ♀ (Japanese) 0.964386 (average level of metabolite) UHPLC-MS/MS Positive mode serum
Linear regression
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
log2 ratio/log2(FC)
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
Summary
  • Synonym:
    N2-gamma-glutamylglutamine; γ-L-Glu-L-Gln; L-gamma-glutamyl-L-glutamine;L-γ-glutamyl-L-glutamine; (5-L-glutamyl)-L-glutamine; gamma-L-Glu-L-Gln
  • Chemical Formula:
    C10H17N3O6
  • Systematic name:
    (2S)-2-amino-5-[[(1S)-4-amino-1-carboxy-4-oxobutyl]amino]-5-oxopentanoic acid
  • SMILES:
    C(CC(=O)NC(CCC(=O)N)C(=O)O)C(C(=O)O)N
  • InChI:
    InChI=1S/C10H17N3O6/c11-5(9(16)17)1-4-8(15)13-6(10(18)19)2-3-7(12)14/h5-6H,1-4,11H2,(H2,12,14)(H,13,15)(H,16,17)(H,18,19)/t5-,6-/m0/s1
  • InChI Key:
    JBFYFLXEJFQWMU-WDSKDSINSA-N
Related resources
Metabolite sources and localization
  • Metabolite location:
    Human organism, Body part, Human body biofluids, Biofluid tissues, Blood, Serum, Cerebrospinal fluid, Organ, Prostate, Tissue, Excreta material, Feces
  • Metabolite source:
    Homo sapiens, endogenous metabolite
Age-variations
Age group comparisons
Method: UHPLC-MS/MS Positive mode
Sample: serum
PubMed PMID: 27374292