gamma-glutamylvaline

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  • Name: gamma-glutamylvaline
  • Description: Gamma-Glutamylvaline is a dipeptide composed of gamma-glutamate and valine. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physi... ological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. gamma-Glutamylvaline belongs to the family of N-acyl-alpha amino acids and derivatives. These are compounds containing an alpha amino acid which bears an acyl group at its terminal nitrogen atom. It is found in urine (PMID: 3782411 ). It is the N-(L-gamma-glutamyl) derivative of L-valine. It has a role as a human metabolite. It is a conjugate acid of a gamma-Glu-Val(1-) (CHEBI:68848).
Overview of age-variations
Age group comparisons
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
27374292 Age [25–35] (median=32), Gender ♀ (Japanese) 0.711724 (average level of metabolite) UHPLC-MS/MS Positive mode serum
27374292 Age [55–65] (median=60), Gender ♀ (Japanese) 0.958411 (average level of metabolite) UHPLC-MS/MS Positive mode serum
27374292 Age [25–35] (median=32), Gender ♂ (Japanese) 1.124068 (average level of metabolite) UHPLC-MS/MS Positive mode serum
27374292 Age [55–64] (median=60), Gender ♂ (Japanese) 1.327789 (average level of metabolite) UHPLC-MS/MS Positive mode serum
Linear regression
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
log2 ratio/log2(FC)
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
Summary
  • Synonym:
    L-gamma-Glu-L-Val;L-γ-Glu-L-Val; L-γ-glutamyl-L-valine; L-gamma-glutamyl-L-valine
  • Chemical Formula:
    C10H18N2O5
  • Systematic name:
    (2S)-2-amino-5-[[(1S)-1-carboxy-2-methylpropyl]amino]-5-oxopentanoic acid
  • SMILES:
    CC(C)C(C(=O)O)NC(=O)CCC(C(=O)O)N
  • InChI:
    InChI=1S/C10H18N2O5/c1-5(2)8(10(16)17)12-7(13)4-3-6(11)9(14)15/h5-6,8H,3-4,11H2,1-2H3,(H,12,13)(H,14,15)(H,16,17)/t6-,8-/m0/s1
  • InChI Key:
    AQAKHZVPOOGUCK-XPUUQOCRSA-N
Related resources
Metabolite sources and localization
  • Metabolite location:
    Human organism, Body part, Human body biofluids, Biofluid tissues, Blood, Serum, Tissue
  • Metabolite source:
    Homo sapiens, endogenous metabolite
Age-variations
Age group comparisons
Method: UHPLC-MS/MS Positive mode
Sample: serum
PubMed PMID: 27374292
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