N2,N2-dimethylguanosine
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Name: N2,N2-dimethylguanosine
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Description: N2,N2-Dimethylguanosine is an urinary nucleoside, a primary degradation product of tRNA. The mean levels of urinary N2,N2-Dimethylguanosine in the patients with colorectal cancer are significantly ...
Overview of age-variations
| Age group comparisons | ||||
|---|---|---|---|---|
| PMID | Age/Age interval, Gender | Value (unit of measurement) | Method | Sample |
| 27036001 | Age 29 ± 4, Gender ⚥ | 0.31 (CV (CV=SD of metabolite abundance (peak areas from LC-MS) divided by the mean)) | LC-MS | blood |
| 27036001 | Age 81 ± 7, Gender ⚥ | 0.44 (CV (CV=SD of metabolite abundance (peak areas from LC-MS) divided by the mean)) | LC-MS | blood |
| 27374292 | Age [25-35], Gender ♀ | 0.838282 (average level of metabolite) | LC/MS positive mode | serum |
| 27374292 | Age [55-65], Gender ♀ | 1.01447 (average level of metabolite) | LC/MS positive mode | serum |
| 27374292 | Age [25-35], Gender ♂ | 1.022728 (average level of metabolite) | LC/MS positive mode | serum |
| 27374292 | Age [55-64], Gender ♂ | 1.224316 (average level of metabolite) | LC/MS positive mode | serum |
| Linear regression | ||||
|---|---|---|---|---|
| PMID | Age/Age interval, Gender | Value (unit of measurement) | Method | Sample |
| log2 ratio/log2(FC) | ||||
|---|---|---|---|---|
| PMID | Age/Age interval, Gender | Value (unit of measurement) | Method | Sample |
Summary
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Synonym:2-(dimethylamino)-9-(b-D-Ribofuranosyl)-1,9-dihydro-6H-purin-6-one;2,2-dimethylguanosine; 2-(dimethylamino)-9-(beta-D-ribofuranosyl)-1,9-dihydro-6H-purin-6-one; 2-(dimethylamino)-9-(β-D-ribofuranosyl)-1,9-dihydro-6H-purin-6-one; 2-(dimethylamino)-9-(beta-D-Ribofuranosyl)-1,9-dihydro-6H-purin-6-one; 2-dimethylamino-6-Oxypurine riboside
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Chemical Formula:C12H17N5O5
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Systematic name:9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-(dimethylamino)-3H-purin-6-one;9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-(dimethylamino)-3H-purin-6-one
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SMILES:CN(C)C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)CO)O)O
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InChI:InChI=1S/C12H17N5O5/c1-16(2)12-14-9-6(10(21)15-12)13-4-17(9)11-8(20)7(19)5(3-18)22-11/h4-5,7-8,11,18-20H,3H2,1-2H3,(H,14,15,21)/t5-,7-,8-,11-/m1/s1
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InChI Key:RSPURTUNRHNVGF-IOSLPCCCSA-N
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CAS number:2140-67-2
Related resources
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Literature sources:
- Chaleckis R et al., Individual variability in human blood metabolites identifies age-related differences., Proceedings of the National Academy of Sciences of the United States of America, 4252-9, 2016
- Saito K et al., Gender- and Age-Associated Differences in Serum Metabolite Profiles among Japanese Populations., Biological & pharmaceutical bulletin, 1179-86, 2016
Metabolite sources and localization
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Metabolite location:Human organism, Body part, Human body biofluids, Biofluid tissues, Blood, Serum, Urine, Tissue, Excreta material
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Metabolite source:Homo sapiens, endogenous metabolite