PC 16:0/18:1

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  • Name: PC 16:0/18:1
  • Description: This metabolite showed statistically significant age-differences in metabolite levels between elderly and centenarians in both genders. POPC is typically considered one of the model lipids for biop... hysical experiments. The fatty acid composition, i.e., saturated chain in the sn-1 position and unsaturated chain in the sn-2 position, mimics mammalian phospholipid composition. Since the major constituent in Egg PC is 1-palmitoyl-2-oleoyl PC, POPC is an excellent synthetic substitute for EPC. (PMID: 24457528; Avanti Polar Lipids:850457)
Overview of age-variations
Age group comparisons
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
24457528 Age 100.7 ± 2.2, Gender ⚥ 351.0 (mean of regulated metabolites) shot gun lipidomics approach serum
24457528 Age 71 ± 6, Gender ⚥ 168.0 (mean of regulated metabolites) shot gun lipidomics approach serum
24457528 Age 100.7 ± 2.3, Gender ♀ 342.0 (mean of regulated metabolites) shot gun lipidomics approach serum
24457528 Age 72 ± 6, Gender ♀ 189.3 (mean of regulated metabolites) shot gun lipidomics approach serum
24457528 Age 100.7 ± 2.3, Gender ♂ 327.9 (mean of regulated metabolites) shot gun lipidomics approach serum
24457528 Age 72 ± 6, Gender ♂ 165.1 (mean of regulated metabolites) shot gun lipidomics approach serum
Linear regression
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
log2 ratio/log2(FC)
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
Summary
  • Synonym:
    POPC
  • Chemical Formula:
    C42H82NO8P
  • Systematic name:
    (3-hexadecanoyloxy-2-octadec-9-enoyloxypropyl) 2-(trimethylazaniumyl)ethyl phosphate
  • SMILES:
    CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC
  • InChI:
    InChI=1S/C42H82NO8P/c1-6-8-10-12-14-16-18-20-21-23-25-27-29-31-33-35-42(45)51-40(39-50-52(46,47)49-37-36-43(3,4)5)38-48-41(44)34-32-30-28-26-24-22-19-17-15-13-11-9-7-2/h20-21,40H,6-19,22-39H2,1-5H3
  • InChI Key:
    WTJKGGKOPKCXLL-UHFFFAOYSA-N
  • CAS number:
    26853-31-6
Related resources
Metabolite sources and localization
  • Metabolite location:
    Human organism, Body part, Human body biofluids, Biofluid tissues, Blood, Serum, Tissue
  • Metabolite source:
    Homo sapiens, endogenous metabolite
Age-variations
Age group comparisons
Method: shot gun lipidomics approach
Sample: serum
PubMed PMID: 24457528
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