isoleucine
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Name: isoleucine
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Description: An unspecified stereoisomerism form of isoleucine. One of nine essential amino acids in humans (present in dietary proteins), Isoleucine has diverse physiological functions, such as assisting wound...
Overview of age-variations
| Age group comparisons | ||||
|---|---|---|---|---|
| PMID | Age/Age interval, Gender | Value (unit of measurement) | Method | Sample |
| 27036001 | Age 29 ± 4, Gender ⚥ | 0.25 (CV (CV=SD of metabolite abundance (peak areas from LC-MS) divided by the mean)) | LC-MS | red blood cells, plasma, blood |
| 27036001 | Age 81 ± 7, Gender ⚥ | 0.35 (CV (CV=SD of metabolite abundance (peak areas from LC-MS) divided by the mean)) | LC-MS | red blood cells, plasma, blood |
| 18384253 | Age 24.5 ± 3, Gender ⚥ | 0.72 (mean value of the compound area) | LC-MS; GC-MS | plasma |
| 18384253 | Age 40.8 ± 5.6, Gender ⚥ | 1.03 (mean value of the compound area) | LC-MS; GC-MS | plasma |
| 18384253 | Age 55.6 ± 3.7, Gender ⚥ | 1.35 (mean value of the compound area) | LC-MS; GC-MS | plasma |
| 27374292 | Age [25–35] (median=32), Gender ♂ (Japanese) | 1.075798 (average level of metabolite) | UHPLC-MS/MS Positive mode | serum |
| 27374292 | Age [55–64] (median=60), Gender ♂ (Japanese) | 1.237545 (average level of metabolite) | UHPLC-MS/MS Positive mode | serum |
| Linear regression | ||||
|---|---|---|---|---|
| PMID | Age/Age interval, Gender | Value (unit of measurement) | Method | Sample |
| log2 ratio/log2(FC) | ||||
|---|---|---|---|---|
| PMID | Age/Age interval, Gender | Value (unit of measurement) | Method | Sample |
Summary
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Synonym:(±)-erythro-isoleucine
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Chemical Formula:C6H13NO2
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Systematic name:2-amino-4-methylpentanoic acid
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SMILES:CCC(C)C(C(=O)O)N
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InChI:InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)
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InChI Key:AGPKZVBTJJNPAG-UHFFFAOYSA-N
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CAS number:328-39-2
Related resources
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Literature sources:
- Chaleckis R et al., Individual variability in human blood metabolites identifies age-related differences., Proceedings of the National Academy of Sciences of the United States of America, 4252-9, 2016
- Lawton KA et al., Analysis of the adult human plasma metabolome., Pharmacogenomics, 383-97, 2008
- Saito K et al., Gender- and Age-Associated Differences in Serum Metabolite Profiles among Japanese Populations., Biological & pharmaceutical bulletin, 1179-86, 2016
Metabolite sources and localization
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Metabolite location:Human organism, Body part, Extracellular, Human body biofluids, Biofluid tissues, Blood, Tissue, Cellular (general class), Subcellular, Cytoplasm
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Metabolite source:Homo sapiens, exogenous metabolite