8-hydroxy-2′-deoxyguanosine

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  • Name: 8-hydroxy-2′-deoxyguanosine
  • Description: 8-hydroxy-deoxyguanosine (8-OHdG) is a sensitive marker of the DNA damage due to hydroxyl radical attack at the C8 of guanine. This damage, if left unrepaired, has been proposed to contribute to mu... tagenicity and cancer promotion (HMDB0003333)
Overview of age-variations
Age group comparisons
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
25147595 Age 21 ± 4.3, Gender ⚥ 11.54 (pg/ml EBC) HPLC/MS body fluid
25147595 Age 39 ± 8.4, Gender ⚥ 14.9 (pg/ml EBC) HPLC/MS body fluid
25147595 Age 62 ± 9.1, Gender ⚥ 24.6 (pg/ml EBC) HPLC/MS body fluid
Linear regression
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
log2 ratio/log2(FC)
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
Summary
  • Synonym:
    8-OXO-dG;8-hydroxydeoxyguanosine
  • Chemical Formula:
    C10H13N5O5
  • Exact Mass g/mol:
    283.0000000
  • Systematic name:
    2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3,7-dihydropurine-6,8-dione
  • SMILES:
    C1C(C(OC1N2C3=C(C(=O)N=C(N3)N)NC2=O)CO)O
  • InChI:
    InChI=1S/C10H13N5O5/c11-9-13-7-6(8(18)14-9)12-10(19)15(7)5-1-3(17)4(2-16)20-5/h3-5,16-17H,1-2H2,(H,12,19)(H3,11,13,14,18)/t3-,4+,5+/m0/s1
  • InChI Key:
    HCAJQHYUCKICQH-VPENINKCSA-N
Related resources
Metabolite sources and localization
  • Metabolite location:
    Human organism, Body part, Human body biofluids, Biofluid tissues, Blood, Cerebrospinal fluid, Urine, Tissue, Cellular (general class), Subcellular, Cytoplasm, Nucleus, Excreta material
  • Metabolite source:
    Homo sapiens, endogenous metabolite
Age-variations
Age group comparisons
Method: HPLC/MS
Sample: body fluid
PubMed PMID: 25147595
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