N-acetyl aspartate

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  • Name: N-acetyl aspartate
  • Description: N-acetylaspartate, is a derivative of aspartic acid with a formula of C6H9NO5 and a molecular weight of 175.139. NAA is the second-most-concentrated molecule in the brain after the amino acid gluta... mate. It is detected in the adult brain in neurons, oligodendrocytes and myelin and is synthesized in the mitochondria from the amino acid aspartic acid and acetyl-coenzyme A. (https://en.wikipedia.org/wiki/N-Acetylaspartic_acid)
Overview of age-variations
Age group comparisons
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
10331768 Age [24-60], Gender ⚥ 11.3 (mmol/l) MR imaging/Spectroscopy parietal white matter
10331768 Age [61-89], Gender ⚥ 11.3 (mmol/l) MR imaging/Spectroscopy parietal white matter
10331768 Age [24-60], Gender ⚥ 12.0 (mmol/l) MR imaging/Spectroscopy occipital gray matter
10331768 Age [61-89], Gender ⚥ 12.6 (mmol/l) MR imaging/Spectroscopy occipital gray matter
22081680 Age 24 ± 2.2, Gender ⚥ 0.26 (x10^(-3) mm^2/s) DW-MRS left centrum semiovale
22081680 Age 63 ± 7, Gender ⚥ 0.19 (x10^(-3) mm^2/s) DW-MRS left centrum semiovale
11158897 Age [21-39], Gender ⚥ 58.0 (%) H-MRS semioval brain region
11158897 Age [40-61], Gender ⚥ 54.0 (%) H-MRS semioval brain region
11158897 Age [21-39], Gender ⚥ 59.0 (%) H-MRS temporal brain region
11158897 Age [40-61], Gender ⚥ 55.0 (%) H-MRS temporal brain region
8371635 Age [20-30], Gender ⚥ 11.4 (mM) H-MRS occipital brain part
8371635 Age [60-80], Gender ⚥ 9.9 (mM) H-MRS occipital brain part
15468140 Age [24-29], Gender ⚥ 8.99 (nM) H-MRS white matter
15468140 Age [46-71], Gender ⚥ 8.39 (nM) H-MRS white matter
15708441 Age 26 ± 1, Gender ⚥ 10.57 (nM) H-MRS motor cortex
15708441 Age 54 ± 6, Gender ⚥ 9.85 (nM) H-MRS motor cortex
Linear regression
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
23709317 Age [20-39], Gender ⚥ 9.952 (β) magnetic resonance anterior cingulate cortex
23709317 Age [40-59], Gender ⚥ 11.807 (β) magnetic resonance anterior cingulate cortex
23709317 Age [60-89], Gender ⚥ 14.418 (β) magnetic resonance anterior cingulate cortex
23709317 Age [20-39], Gender ⚥ 11.85 (β) magnetic resonance posterior cingulate cortex
23709317 Age [40-59], Gender ⚥ 13.442 (β) magnetic resonance posterior cingulate cortex
23709317 Age [60-89], Gender ⚥ 13.354 (β) magnetic resonance posterior cingulate cortex
30659340 Age [20-70], Gender ⚥ -0.0299 (β) wbMRSI parietal white matter
30659340 Age [20-70], Gender ⚥ -0.0384 (β) wbMRSI occipital gray matter
30659340 Age [20-70], Gender ⚥ -0.058 (β) Hybrid occipital gray matter
30659340 Age [20-70], Gender ⚥ -0.0818 (β) Hybrid parietal white matter
log2 ratio/log2(FC)
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
Summary
  • Synonym:
    2-acetamidobutanedioate
  • Chemical Formula:
    C6H7NO5-2
  • Exact Mass g/mol:
    173.0000000
  • Systematic name:
    2-acetamidobutanedioate
  • SMILES:
    CC(=O)NC(CC(=O)[O-])C(=O)[O-]
  • InChI:
    InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2
  • InChI Key:
    OTCCIMWXFLJLIA-UHFFFAOYSA-L
Related resources
Metabolite sources and localization
  • Metabolite location:
    Human organism, Body part, Human body biofluids, Urine, Organ, Brain, Cerebral cortex, Cingulate cortex, Anterior cingulate cortex, Posterior cingulate cortex, Motor cortex, White metter, Lateral ventricles, Corona radiata, Occipital lobe, Occipital gray matter, Parietal lobe, Parietal white matter, Spinal cord, Tissue, Nervous tissue, Excreta material
Age-variations
Age group comparisons
Method: MR imaging/Spectroscopy
Sample: parietal white matter
PubMed PMID: 10331768
Age group comparisons
Method: MR imaging/Spectroscopy
Sample: occipital gray matter
PubMed PMID: 10331768
Age group comparisons
Method: DW-MRS
Sample: left centrum semiovale
PubMed PMID: 22081680
Age group comparisons
Method: H-MRS
Sample: semioval brain region
PubMed PMID: 11158897
Age group comparisons
Method: H-MRS
Sample: temporal brain region
PubMed PMID: 11158897
Age group comparisons
Method: H-MRS
Sample: occipital brain part
PubMed PMID: 8371635
Age group comparisons
Method: H-MRS
Sample: white matter
PubMed PMID: 15468140
Age group comparisons
Method: H-MRS
Sample: motor cortex
PubMed PMID: 15708441
Linear regression
Method: magnetic resonance
Sample: anterior cingulate cortex
PubMed PMID: 23709317
β = 9.952 (y = βx + α)
p-value < 0.05
Linear regression
Method: magnetic resonance
Sample: anterior cingulate cortex
PubMed PMID: 23709317
β = 11.807 (y = βx + α)
p-value < 0.05
Linear regression
Method: magnetic resonance
Sample: anterior cingulate cortex
PubMed PMID: 23709317
β = 14.418 (y = βx + α)
p-value < 0.05
Linear regression
Method: magnetic resonance
Sample: posterior cingulate cortex
PubMed PMID: 23709317
β = 11.85 (y = βx + α)
p-value < 0.05
Linear regression
Method: magnetic resonance
Sample: posterior cingulate cortex
PubMed PMID: 23709317
β = 13.442 (y = βx + α)
p-value < 0.05
Linear regression
Method: magnetic resonance
Sample: posterior cingulate cortex
PubMed PMID: 23709317
β = 13.354 (y = βx + α)
p-value < 0.05
Linear regression
Method: wbMRSI
Sample: parietal white matter
PubMed PMID: 30659340
β = -0.0299 (y = βx + α)
p-value < 0.05
Linear regression
Method: wbMRSI
Sample: occipital gray matter
PubMed PMID: 30659340
β = -0.0384 (y = βx + α)
p-value < 0.05
Linear regression
Method: Hybrid
Sample: occipital gray matter
PubMed PMID: 30659340
β = -0.058 (y = βx + α)
p-value < 0.05
Linear regression
Method: Hybrid
Sample: parietal white matter
PubMed PMID: 30659340
β = -0.0818 (y = βx + α)
p-value < 0.05
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