15-hydroxy-eicosatrienoic acid

view
  • Name: 15-hydroxy-eicosatrienoic acid
  • Description: 5(S)-hydroxyeicosatrienoic acid (15S-HETrE) is the in vivo metabolite of gamma-linolenic acid, a polyunsaturated fatty acid that have been reported to modulate arachidonic acid (AA) metabolism and ... tumorigenesis. 15S-HETrE suppress cyclooxygenase-2 (COX-2) over expression and/or Prostaglandin E2 (PGE2) biosynthesis (PMID 15197770 ), and inhibits [(3)H]thymidine uptake in parallel with the upregulation of peroxisome proliferator-activated receptor-gamma expression (a growth modulating nuclear receptor, PPARgamma). (PMID 12445673 ).
Overview of age-variations
Age group comparisons
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
23483888 Age 30 ± 5 , Gender ⚥ 1.512 (ng/100 μl serum) LC-MS/MS serum
23483888 Age 70.7 ± 6, Gender ⚥ 1.255 (ng/100 μl serum) LC-MS/MS serum
23483888 Age 100.9 ± 2, Gender ⚥ 3.348 (ng/100 μl serum) LC-MS/MS serum
Linear regression
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
log2 ratio/log2(FC)
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
Summary
  • Synonym:
    15-HETE
  • Chemical Formula:
    C20H32O3
  • Systematic name:
    (5Z,8Z,11Z,13E)-15-hydroxyicosa-5,8,11,13-tetraenoic acid
  • SMILES:
    CCCCCC(C=CC=CCC=CCC=CCCCC(=O)O)O
  • InChI:
    InChI=1S/C20H32O3/c1-2-3-13-16-19(21)17-14-11-9-7-5-4-6-8-10-12-15-18-20(22)23/h4-5,8-11,14,17,19,21H,2-3,6-7,12-13,15-16,18H2,1H3,(H,22,23)/b5-4-,10-8-,11-9-,17-14+
  • InChI Key:
    JSFATNQSLKRBCI-USWFWKISSA-N
Related resources
Metabolite sources and localization
  • Metabolite location:
    Human organism, Body part, Human body biofluids, Biofluid tissues, Blood, Serum, Urine, Tissue, Excreta material
  • Metabolite source:
    Homo sapiens, endogenous metabolite
Age-variations
Age group comparisons
Method: LC-MS/MS
Sample: serum
PubMed PMID: 23483888
Search the database by metabolite name or synonym