valine

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  • Name: valine
  • Description: An unspecified stereoisomerism form of valine (symbol Val or V) which is an α-amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated −NH3+... form under biological conditions), an α-carboxylic acid group (which is in the deprotonated −COO− form under biological conditions), and a side chain isopropyl group, making it a non-polar aliphatic amino acid. It is essential in humans, meaning the body cannot synthesize it: it must be obtained from the diet. Human dietary sources are foods that contain protein, such as meats, dairy products, soy products, beans and legumes. It is encoded by all codons starting with GU (GUU, GUC, GUA, and GUG). Like leucine and isoleucine, valine is a branched-chain amino acid. In sickle-cell disease, a single glutamic acid in β-globin is replaced with valine. Because valine is hydrophobic, whereas glutamic acid is hydrophilic, this change makes the hemoglobin prone to abnormal aggregation. (HMDB0000883)
Overview of age-variations
Age group comparisons
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
18384253 Age 24.5 ± 3, Gender ⚥ 0.7 (mean value of the compund area) LC-MS; GC-MS plasma
18384253 Age 40.8 ± 5.6, Gender ⚥ 1.01 (mean value of the compund area) LC-MS; GC-MS plasma
18384253 Age 55.6 ± 3.7, Gender ⚥ 1.33 (mean value of the compund area) LC-MS; GC-MS plasma
12768504 Age 32.6 ± 4.4 , Gender ♀ 216.0 (μmol/l) LC blood
12768504 Age 48 ± 4.3, Gender ♀ 204.0 (μmol/l) LC blood
12768504 Age 74.7 ± 10, Gender ♀ 186.0 (μmol/l) LC blood
12768504 Age 33.3 ± 3.8, Gender ♂ 250.0 (μmol/l) LC blood
12768504 Age 48.4 ± 6, Gender ♂ 267.0 (μmol/l) LC blood
12768504 Age 75.9 ± 9.3, Gender ♂ 231.0 (μmol/l) LC blood
Linear regression
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
log2 ratio/log2(FC)
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
Summary
  • Chemical Formula:
    C5H11NO2
  • Systematic name:
    2-amino-3-methylbutanoic acid
  • SMILES:
    CC(C)C(C(=O)O)N
  • InChI:
    InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)
  • InChI Key:
    KZSNJWFQEVHDMF-UHFFFAOYSA-N
  • CAS number:
    516-06-03
Related resources
Metabolite sources and localization
  • Metabolite location:
    Human organism, Body part, Human body biofluids, Biofluid tissues, Blood, Plasma, Tissue
  • Metabolite source:
    Homo sapiens, exogenous metabolite
Age-variations
Age group comparisons
Method: LC-MS; GC-MS
Sample: plasma
PubMed PMID: 18384253
Age group comparisons
Method: LC
Sample: blood
PubMed PMID: 12768504
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