histidine

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  • Name: histidine
  • Description: An unspecified stereoisomerism form of histidine which is an an α-amino acid that is propanoic acid bearing an amino substituent at position 2 and a 1H-imidazol-4-yl group at position 3. It is one ... of the 22 proteinogenic amino acids. Histidine was first isolated by German physician Albrecht Kossel in 1896. Histidine is an essential amino acid in humans and other mammals. It was initially thought that it was only essential for infants, but longer-term studies established that it is also essential for adults. Infants four to six months old require 33 mg/kg of histidine. It is not clear how adults make small amounts of histidine, and dietary sources probably account for most of the histidine in the body. Histidine is a precursor for histamine and carnosine biosynthesis. Inborn errors of histidine metabolism, including histidinemia, maple syrup urine disease, propionic acidemia, and tyrosinemia I, exist and are marked by increased histidine levels in the blood. Elevated blood histidine is accompanied by a wide range of symptoms, from mental and physical retardation to poor intellectual functioning, emotional instability, tremor, ataxia and psychosis. Histidine and other imidazole compounds have anti-oxidant, anti-inflammatory and anti-secretory properties (PMID: 9605177 ). (CHEBI:27570, http://www.dcnutrition.com)
Overview of age-variations
Age group comparisons
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
18384253 Age 24.5 ± 3, Gender ⚥ 0.77 (mean value of the compound area) LC-MS; GC-MS plasma
18384253 Age 40.8 ± 5.6, Gender ⚥ 1.09 (mean value of the compound area) LC-MS; GC-MS plasma
18384253 Age 55.6 ± 3.7, Gender ⚥ 1.18 (mean value of the compound area) LC-MS; GC-MS plasma
12768504 Age 32.6 ± 4.4 , Gender ♀ 98.0 (μmol/l) LC blood
12768504 Age 48 ± 4.3, Gender ♀ 96.0 (μmol/l) LC blood
12768504 Age 74.7 ± 10, Gender ♀ 81.0 (μmol/l) LC blood
12768504 Age 33.3 ± 3.8, Gender ♂ 112.0 (μmol/l) LC blood
12768504 Age 48.4 ± 6, Gender ♂ 107.0 (μmol/l) LC blood
12768504 Age 75.9 ± 9.3, Gender ♂ 88.0 (μmol/l) LC blood
Linear regression
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
22834969 Age 54.1 ± 13.1, Gender ♀ -0.18 (β) FIA-MS/MS serum
22834969 Age 57.7 ± 10.6, Gender ♀ -0.1 (β) FIA-MS/MS serum
22834969 Age 53.6 ± 12.5, Gender ♂ -0.29 (β) FIA-MS/MS serum
log2 ratio/log2(FC)
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
29090929 Age 41 ± 12, Gender ♂ 0.165 (log2 ratio) NMR blood
Summary
  • Chemical Formula:
    C6H9N3O2
  • Systematic name:
    2-amino-3-(1H-imidazol-4-yl)propanoic acid
  • SMILES:
    C1=C(NC=N1)CC(C(=O)O)N
  • InChI:
    InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)
  • InChI Key:
    HNDVDQJCIGZPNO-UHFFFAOYSA-N
  • CAS number:
    4998-57-6
Related resources
Metabolite sources and localization
  • Metabolite location:
    Human organism, Body part, Human body biofluids, Biofluid tissues, Blood, Serum, Tissue
  • Metabolite source:
    Homo sapiens, exogenous metabolite
Age-variations
Age group comparisons
Method: LC-MS; GC-MS
Sample: plasma
PubMed PMID: 18384253
Age group comparisons
Method: LC
Sample: blood
PubMed PMID: 12768504
Linear regression
Method: FIA-MS/MS
Sample: serum
PubMed PMID: 22834969
β = -0.18 (y = βx + α)
p-value < 0.05
Linear regression
Method: FIA-MS/MS
Sample: serum
PubMed PMID: 22834969
β = -0.1 (y = βx + α)
p-value < 0.05
Linear regression
Method: FIA-MS/MS
Sample: serum
PubMed PMID: 22834969
β = -0.29 (y = βx + α)
p-value < 0.05
Fold-change with age
Method: NMR
Sample: blood
PubMed PMID: 29090929
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