tryptophan
-
Name: tryptophan
-
Description: An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its...
Overview of age-variations
| Age group comparisons | ||||
|---|---|---|---|---|
| PMID | Age/Age interval, Gender | Value (unit of measurement) | Method | Sample |
| 18384253 | Age 24.5 ± 3, Gender ⚥ | 1.0 (mean value of the compound area) | LC-MS; GC-MS | plasma |
| 18384253 | Age 40.8 ± 5.6, Gender ⚥ | 0.95 (mean value of the compound area) | LC-MS; GC-MS | plasma |
| 18384253 | Age 55.6 ± 3.7, Gender ⚥ | 1.03 (mean value of the compound area) | LC-MS; GC-MS | plasma |
| 23483888 | Age 30 ± 5 , Gender ⚥ | 87.7 (ng/100 μl serum) | LC-MS/MS | serum |
| 23483888 | Age 70.7 ± 6, Gender ⚥ | 80.5 (ng/100 μl serum) | LC-MS/MS | serum |
| 23483888 | Age 100.9 ± 2, Gender ⚥ | 71.3 (ng/100 μl serum) | LC-MS/MS | serum |
| 12768504 | Age 32.6 ± 4.4 , Gender ♀ | 50.0 (μmol/l) | LC | blood |
| 12768504 | Age 48 ± 4.3, Gender ♀ | 51.0 (μmol/l) | LC | blood |
| 12768504 | Age 74.7 ± 10, Gender ♀ | 46.0 (μmol/l) | LC | blood |
| 12768504 | Age 33.3 ± 3.8, Gender ♂ | 65.0 (μmol/l) | LC | blood |
| 12768504 | Age 48.4 ± 6, Gender ♂ | 54.0 (μmol/l) | LC | blood |
| 12768504 | Age 75.9 ± 9.3, Gender ♂ | 55.0 (μmol/l) | LC | blood |
| Linear regression | ||||
|---|---|---|---|---|
| PMID | Age/Age interval, Gender | Value (unit of measurement) | Method | Sample |
| 22834969 | Age 54.1 ± 13.1, Gender ♀ | -0.24 (β) | FIA-MS/MS | serum |
| 22834969 | Age 53.6 ± 12.5, Gender ♂ | -0.46 (β) | FIA-MS/MS | serum |
| log2 ratio/log2(FC) | ||||
|---|---|---|---|---|
| PMID | Age/Age interval, Gender | Value (unit of measurement) | Method | Sample |
| 26088811 | Age 40.9 ± 10.3, Gender ⚥ | -0.91 (log2 ratio) | UHPLC negative mode | urine |
Summary
-
Chemical Formula:C11H12N2O2
-
Exact Mass g/mol:204.0898776
-
Systematic name:alpha-Amino-beta-(3-indolyl)-propionic acid;(2S)-2-amino-3-(1H-indol-3-yl)propanoic acid
-
SMILES:C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)N
-
InChI:InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)
-
InChI Key:QIVBCDIJIAJPQS-UHFFFAOYSA-N
-
CAS number:73-22-3; 54-12-6; 27813-82-7
Related resources
-
Literature sources:
- Lawton KA et al., Analysis of the adult human plasma metabolome., Pharmacogenomics, 383-97, 2008
- Collino S et al., Metabolic signatures of extreme longevity in northern Italian centenarians reveal a complex remodeling of lipids, amino acids, and gut microbiota metabolism., PloS one, e56564, 2013
- Pitkänen HT et al., Serum amino acid concentrations in aging men and women., Amino acids, 413-21, 2003
- Thévenot EA et al., Analysis of the Human Adult Urinary Metabolome Variations with Age, Body Mass Index, and Gender by Implementing a Comprehensive Workflow for Univariate and OPLS Statistical Analyses., Journal of proteome research, 3322-35, 2015
- Yu Z et al., Human serum metabolic profiles are age dependent., Aging cell, 960-7, 2012
Metabolite sources and localization
-
Metabolite location:Human organism, Body part, Human body biofluids, Biofluid tissues, Blood, Plasma, Cerebrospinal fluid, Breast milk, Saliva, Sweat, Urine, Organ, Prostate, Tissue, Connective tissue, Connective tissue cell, Fibroblast, Nervous tissue, Nervous tissue cells, Nerve cell, Excreta material, Feces
-
Metabolite source:Homo sapiens, exogenous metabolite
Age-variations
Linear regression
Method: FIA-MS/MS
Sample: serum
β = -0.24
(y = βx + α)
p-value < 0.05
Linear regression
Method: FIA-MS/MS
Sample: serum
β = -0.46
(y = βx + α)
p-value < 0.05