alanine

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  • Name: alanine
  • Description: An unspecified stereoisomerism form of alanine which is a non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is invo... lved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM. (HMDB0062251)
Overview of age-variations
Age group comparisons
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
18384253 Age 24.5 ± 3, Gender ⚥ 0.72 (mean value of the compound area) LC-MS; GC-MS plasma
18384253 Age 40.8 ± 5.6, Gender ⚥ 1.03 (mean value of the compound area) LC-MS; GC-MS plasma
18384253 Age 55.6 ± 3.7, Gender ⚥ 1.42 (mean value of the compound area) LC-MS; GC-MS plasma
17474139 Age 36.6 ± 5.5, Gender ⚥ 33.8 (mmol/mol ) H-NMR urine
17474139 Age 54.5 ± 7.6, Gender ⚥ 34.1 (mmol/mol ) H-NMR urine
23701591 Age [34-39], Gender ⚥ (American population) 2.0 (signal intensity) HNMR urine
23701591 Age [72-84], Gender ⚥ (American population) 1.68 (signal intensity) HNMR urine
27374292 Age [25–35] (median=32), Gender ♀ (Japanese) 0.927251 (average level of metabolite) UHPLC-MS/MS Positive mode serum
27374292 Age [55–65] (median=60), Gender ♀ (Japanese) 1.00017 (average level of metabolite) UHPLC-MS/MS Positive mode serum
27374292 Age [25–35] (median=32), Gender ♂ (Japanese) 0.965668 (average level of metabolite) UHPLC-MS/MS Positive mode serum
27374292 Age [55–64] (median=60), Gender ♂ (Japanese) 1.133156 (average level of metabolite) UHPLC-MS/MS Positive mode serum
Linear regression
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
log2 ratio/log2(FC)
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
29090929 Age 42 ± 12, Gender ♀ -0.24 (log2 ratio) NMR blood
29090929 Age 41 ± 12, Gender ♂ -0.127 (log2 ratio) NMR blood
Summary
  • Synonym:
    Ala
  • Chemical Formula:
    C3H7NO2
  • Exact Mass g/mol:
    89.0480000
  • Systematic name:
    2-aminopropanoic acid
  • SMILES:
    CC(C(=O)O)N
  • InChI:
    InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)
  • InChI Key:
    QNAYBMKLOCPYGJ-UHFFFAOYSA-N
  • CAS number:
    302-72-7
Related resources
Metabolite sources and localization
  • Metabolite location:
    Human organism, Body part, Human body biofluids, Biofluid tissues, Blood, Plasma, Urine, Tissue, Excreta material
  • Metabolite source:
    Homo sapiens, endogenous metabolite
Age-variations
Age group comparisons
Method: LC-MS; GC-MS
Sample: plasma
PubMed PMID: 18384253
Age group comparisons
Method: H-NMR
Sample: urine
PubMed PMID: 17474139
Age group comparisons
Method: HNMR
Sample: urine
PubMed PMID: 23701591
Age group comparisons
Method: UHPLC-MS/MS Positive mode
Sample: serum
PubMed PMID: 27374292
Fold-change with age
Method: NMR
Sample: blood
PubMed PMID: 29090929
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