tyrosine
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Name: tyrosine
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Description: An unspecified stereoisomerism form of glycine (symbol Gly or G; ) which is the amino acid that has a single hydrogen atom as its side chain. It is the simplest possible amino acid. The chemical fo...
Overview of age-variations
| Age group comparisons | ||||
|---|---|---|---|---|
| PMID | Age/Age interval, Gender | Value (unit of measurement) | Method | Sample |
| 18384253 | Age 24.5 ± 3, Gender ⚥ | 0.97 (mean value of the compound area) | LC-MS; GC-MS | plasma |
| 18384253 | Age 40.8 ± 5.6, Gender ⚥ | 1.0 (mean value of the compound area) | LC-MS; GC-MS | plasma |
| 18384253 | Age 55.6 ± 3.7, Gender ⚥ | 1.06 (mean value of the compound area) | LC-MS; GC-MS | plasma |
| 30113646 | Age 44.6 ± 14, Gender ♀ (Dutch) | 51.9 (μmol/L) | LC-MS/MS | plasma |
| 30113646 | Age 44.6 ± 13, Gender ♀ (South-Asian Surinamese) | 57.1 (μmol/L) | LC-MS/MS | plasma |
| 30113646 | Age 44.6 ± 14, Gender ♀ (Dutch) | 105.9 (% (percentage of metabolite concentration compared with baseline (100%) per 10 year increment in age; analyses were adjusted for BMI)) | LC-MS/MS | plasma |
| 30113646 | Age 44.6 ± 13, Gender ♀ (South-Asian Surinamese) | 104.1 (% (percentage of metabolite concentration compared with baseline (100%) per 10 year increment in age; analyses were adjusted for BMI)) | LC-MS/MS | plasma |
| 27374292 | Age [25–35] (median=32), Gender ♂ (Japanese) | 0.988592 (average level of metabolite) | UHPLC-MS/MS Positive mode | serum |
| 27374292 | Age [55–64] (median=60), Gender ♂ (Japanese) | 1.126958 (average level of metabolite) | UHPLC-MS/MS Positive mode | serum |
| Linear regression | ||||
|---|---|---|---|---|
| PMID | Age/Age interval, Gender | Value (unit of measurement) | Method | Sample |
| 30841604 | Age [25-74], Gender ♀ | 0.11 (β) | indirect potentiometry | serum |
| 30841604 | Age [45-80], Gender ♀ | 0.05 (β) | FIA-ESI-MS/MS | serum |
| log2 ratio/log2(FC) | ||||
|---|---|---|---|---|
| PMID | Age/Age interval, Gender | Value (unit of measurement) | Method | Sample |
| 29090929 | Age 42 ± 12, Gender ♀ | -0.319 (log2 ratio) | NMR | blood |
| 29090929 | Age 41 ± 12, Gender ♂ | -0.124 (log2 ratio) | NMR | blood |
Summary
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Synonym:Tyr
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Chemical Formula:C9H11NO3
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Exact Mass g/mol:181.0740000
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Systematic name:2-amino-3-(4-hydroxyphenyl)propanoic acid
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SMILES:C1=CC(=CC=C1CC(C(=O)O)N)O
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InChI:InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)
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InChI Key:OUYCCCASQSFEME-UHFFFAOYSA-N
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CAS number:556-03-06
Related resources
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Literature sources:
- Lawton KA et al., Analysis of the adult human plasma metabolome., Pharmacogenomics, 383-97, 2008
- Saito K et al., Gender- and Age-Associated Differences in Serum Metabolite Profiles among Japanese Populations., Biological & pharmaceutical bulletin, 1179-86, 2016
- Muilwijk M et al., The Association of Acylcarnitines and Amino Acids With Age in Dutch and South-Asian Surinamese Living in Amsterdam., The Journal of clinical endocrinology and metabolism, 3783-3791, 2018
- Vignoli A et al., Age and Sex Effects on Plasma Metabolite Association Networks in Healthy Subjects., Journal of proteome research, 97-107, 2018
- Chak CM et al., Ageing Investigation Using Two-Time-Point Metabolomics Data from KORA and CARLA Studies., Metabolites, , 2019
Metabolite sources and localization
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Metabolite location:Human organism, Body part, Human body biofluids, Biofluid tissues, Blood, Plasma, Tissue
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Metabolite source:Homo sapiens, endogenous metabolite
Age-variations
Linear regression
Method: indirect potentiometry
Sample: serum
β = 0.11
(y = βx + α)
p-value < 0.05
Linear regression
Method: FIA-ESI-MS/MS
Sample: serum
β = 0.05
(y = βx + α)
p-value < 0.05