oxoproline

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  • Name: oxoproline
  • Description: A pyrrolidinemonocarboxylic acid consisting of proline bearing a single oxo substituent. Pyrrolidonecarboxylic acid, also known as pyroglutamate or pyroglutamic acid, belongs to the class of organi... c compounds known as proline and derivatives. Proline and derivatives are compounds containing proline or a derivative thereof resulting from reaction of proline at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. Pyrrolidonecarboxylic acid exists as a solid, soluble (in water), and a weakly acidic compound (based on its pKa). Pyrrolidonecarboxylic acid has been detected in multiple biofluids, such as saliva and sweat. Within the cell, pyrrolidonecarboxylic acid is primarily located in the cytoplasm. (HMDB0060262)
Overview of age-variations
Age group comparisons
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
18384253 Age 24.5 ± 3, Gender ⚥ 0.87 (mean value of the compound area) LC-MS; GC-MS plasma
18384253 Age 40.8 ± 5.6, Gender ⚥ 1.05 (mean value of the compound area) LC-MS; GC-MS plasma
18384253 Age 55.6 ± 3.7, Gender ⚥ 1.13 (mean value of the compound area) LC-MS; GC-MS plasma
Linear regression
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
log2 ratio/log2(FC)
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
Summary
  • Chemical Formula:
    C5H7NO3
  • Exact Mass g/mol:
    129.0430000
  • Systematic name:
    5-oxopyrrolidine-2-carboxylic acid
  • SMILES:
    C1CC(=O)NC1C(=O)O
  • InChI:
    InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)
  • InChI Key:
    ODHCTXKNWHHXJC-UHFFFAOYSA-N
  • CAS number:
    149-87-1
Related resources
Pathway info P = product of S = substrate of
Metabolite sources and localization
  • Metabolite location:
    Human organism, Body part, Human body biofluids, Biofluid tissues, Blood, Plasma, Tissue
  • Metabolite source:
    Homo sapiens, endogenous metabolite
Age-variations
Age group comparisons
Method: LC-MS; GC-MS
Sample: plasma
PubMed PMID: 18384253