ornithine
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Name: ornithine
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Description: Ornithine is an alpha-amino acid that is pentanoic acid bearing two amino substituents at positions 2 and 5. It has a role as a human metabolite, a Daphnia magna metabolite, an algal metabolite and...
Overview of age-variations
| Age group comparisons | ||||
|---|---|---|---|---|
| PMID | Age/Age interval, Gender | Value (unit of measurement) | Method | Sample |
| 18384253 | Age 24.5 ± 3, Gender ⚥ | 0.56 (mean value of the compound area) | LC-MS; GC-MS | plasma |
| 18384253 | Age 40.8 ± 5.6, Gender ⚥ | 1.1 (mean value of the compound area) | LC-MS; GC-MS | plasma |
| 18384253 | Age 55.6 ± 3.7, Gender ⚥ | 1.73 (mean value of the compound area) | LC-MS; GC-MS | plasma |
| 27374292 | Age [25–35] (median=32), Gender ♀ (Japanese) | 0.800746 (average level of metabolite) | UHPLC-MS/MS HILIC | serum |
| 27374292 | Age [55–65] (median=60), Gender ♀ (Japanese) | 1.017799 (average level of metabolite) | UHPLC-MS/MS HILIC | serum |
| Linear regression | ||||
|---|---|---|---|---|
| PMID | Age/Age interval, Gender | Value (unit of measurement) | Method | Sample |
| 30841604 | Age [25-74], Gender ♀ | 0.14 (β) | indirect potentiometry | serum |
| 30841604 | Age [45-80], Gender ♀ | 0.24 (β) | FIA-ESI-MS/MS | serum |
| 30841604 | Age [25-74], Gender ♂ | 0.14 (β) | indirect potentiometry | serum |
| 30841604 | Age [45-80], Gender ♂ | 0.22 (β) | FIA-ESI-MS/MS | serum |
| log2 ratio/log2(FC) | ||||
|---|---|---|---|---|
| PMID | Age/Age interval, Gender | Value (unit of measurement) | Method | Sample |
Summary
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Synonym:2,5-diaminovaleric acid; DL-ornithine; alpha, delta-diaminopentanoic acid; alpha, delta-diaminovaleric acid
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Chemical Formula:C5H12N2O2
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Exact Mass g/mol:132.0898780
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Systematic name:2,5-diaminopentanoic acid
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SMILES:C(CC(C(=O)O)N)CN
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InChI:InChI=1S/C5H12N2O2/c6-3-1-2-4(7)5(8)9/h4H,1-3,6-7H2,(H,8,9)
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InChI Key:AHLPHDHHMVZTML-UHFFFAOYSA-N
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CAS number:616-07-09
Related resources
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Literature sources:
- Lawton KA et al., Analysis of the adult human plasma metabolome., Pharmacogenomics, 383-97, 2008
- Saito K et al., Gender- and Age-Associated Differences in Serum Metabolite Profiles among Japanese Populations., Biological & pharmaceutical bulletin, 1179-86, 2016
- Chak CM et al., Ageing Investigation Using Two-Time-Point Metabolomics Data from KORA and CARLA Studies., Metabolites, , 2019
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External links:
Metabolite sources and localization
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Metabolite location:Human organism, Body part, Human body biofluids, Biofluid tissues, Blood, Plasma, Tissue
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Metabolite source:Homo sapiens, endogenous metabolite
Age-variations
Linear regression
Method: indirect potentiometry
Sample: serum
β = 0.14
(y = βx + α)
p-value < 0.05
Linear regression
Method: FIA-ESI-MS/MS
Sample: serum
β = 0.24
(y = βx + α)
p-value < 0.05
Linear regression
Method: indirect potentiometry
Sample: serum
β = 0.14
(y = βx + α)
p-value < 0.05
Linear regression
Method: FIA-ESI-MS/MS
Sample: serum
β = 0.22
(y = βx + α)
p-value < 0.05