p-cresol sulfate

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  • Name: p-cresol sulfate
  • Description: p-Cresol sulfate is a microbial metabolite that is found in urine and likely derives from secondary metabolism of p-cresol. It appears to be elevated in the urine of individuals with progressive mu... ltiple sclerosis (PMID: 10775436). p-Cresol sulfate is the major component of urinary MBPLM (myelin basic protein-like material). p-Cresol sulfate is a small protein-bound molecule that is poorly cleared with dialysis and is often considered to be a uremic toxin. Uremic toxins include low-molecular-weight compounds such as indoxyl sulfate, p-cresol sulfate, 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid, and asymmetric dimethylarginine (PMID: 18941347). It has also been linked to cardiovascular disease and oxidative injury. (HMDB0011635)
Overview of age-variations
Age group comparisons
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
18384253 Age 24.5 ± 3, Gender ⚥ 0.58 (mean value of the compound area) LC-MS; GC-MS plasma
18384253 Age 40.8 ± 5.6, Gender ⚥ 0.81 (mean value of the compound area) LC-MS; GC-MS plasma
18384253 Age 55.6 ± 3.7, Gender ⚥ 1.05 (mean value of the compound area) LC-MS; GC-MS plasma
27240996 Age [20-29], Gender ⚥ 2.65 (mg/l) HPLC/MS/MS serum
27240996 Age [30-39], Gender ⚥ 2.31 (mg/l) HPLC/MS/MS serum
27240996 Age [40-49], Gender ⚥ 3.22 (mg/l) HPLC/MS/MS serum
27240996 Age [50-59], Gender ⚥ 2.88 (mg/l) HPLC/MS/MS serum
27240996 Age [60-69], Gender ⚥ 4.03 (mg/l) HPLC/MS/MS serum
27240996 Age [70-90], Gender ⚥ 4.9 (mg/l) HPLC/MS/MS serum
Linear regression
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
log2 ratio/log2(FC)
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
Summary
  • Synonym:
    4-cresol sulfate; p-cresyl sulfate
  • Chemical Formula:
    C7H8O4S
  • Exact Mass g/mol:
    188.0140000
  • Systematic name:
    (4-methylphenyl) hydrogen sulfate
  • SMILES:
    CC1=CC=C(C=C1)OS(=O)(=O)O
  • InChI:
    InChI=1S/C7H8O4S/c1-6-2-4-7(5-3-6)11-12(8,9)10/h2-5H,1H3,(H,8,9,10)
  • InChI Key:
    WGNAKZGUSRVWRH-UHFFFAOYSA-N
  • CAS number:
    3233-58-7
Related resources
Metabolite sources and localization
  • Metabolite location:
    Human organism, Body part, Human body biofluids, Biofluid tissues, Blood, Plasma, Saliva, Urine, Tissue, Excreta material, Feces
  • Metabolite source:
    Homo sapiens, endogenous metabolite
Age-variations
Age group comparisons
Method: LC-MS; GC-MS
Sample: plasma
PubMed PMID: 18384253

Age group comparisons
Method: HPLC/MS/MS
Sample: serum
PubMed PMID: 27240996