acetylcarnosine

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  • Name: acetylcarnosine
  • Description: N-Acetylcarnosine (NAC) is a naturally-occurring compound chemically related to the dipeptide carnosine. Its molecular structure is similar to carnosine with the exception that it carries an additi... onal acetyl group. This makes NAC a more stable molecule which is not easily destroyed by carnosinase, an enzyme that breaks down carnosine to its constituent amino acids, beta-alanine and histidine. NAC is a free-radical scavenger and is particularly active against lipid peroxidation in the different parts of the lens in the eye. It is the active ingredient of eye drops used in order to prevent or treat cataract. (HMDB0012881)
Overview of age-variations
Age group comparisons
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
27036001 Age 29 ± 4, Gender ⚥ 0.75 (CV (CV=SD of metabolite abundance (peak areas from LC-MS) divided by the mean)) LC/MS blood
27036001 Age 81 ± 7, Gender ⚥ 0.24 (CV (CV=SD of metabolite abundance (peak areas from LC-MS) divided by the mean)) LC/MS blood
Linear regression
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
log2 ratio/log2(FC)
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
Summary
  • Synonym:
    N-acetylcarnosine;CL 1700; N-acetylcarnosine,(DL)-isomer; N-acetyl-L-carnosine aluminum
  • Chemical Formula:
    C11H16N4O4
  • Systematic name:
    (2S)-2-(3-acetamidopropanoylamino)-3-(1H-imidazol-5-yl)propanoic acid
  • SMILES:
    CC(=O)NCCC(=O)N[C@@H](Cc1cnc[nH]1)C(O)=O
  • InChI:
    InChI=1S/C11H16N4O4/c1-7(16)13-3-2-10(17)15-9(11(18)19)4-8-5-12-6-14-8/h5-6,9H,2-4H2,1H3,(H,12,14)(H,13,16)(H,15,17)(H,18,19)/t9-/m0/s1
  • InChI Key:
    BKAYIFDRRZZKNF-VIFPVBQESA-N
  • CAS number:
    56353-15-2
Related resources
Metabolite sources and localization
  • Metabolite location:
    Human organism, Body part, Human body biofluids, Biofluid tissues, Blood, Organ, Eye, Tissue
  • Metabolite source:
    Homo sapiens, endogenous metabolite
Age-variations
Age group comparisons
Method: LC/MS
Sample: blood
PubMed PMID: 27036001
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