gamma-glutamyltyrosine

Info Variations

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Name: gamma-glutamyltyrosine
Description: gamma-Glutamyltyrosine is a dipeptide composed of gamma-glutamate and tyrosine, and is a proteolytic breakdown product of larger proteins. It belongs to the family of N-acyl-alpha amino acids and d... erivatives. These are compounds containing an alpha amino acid which bears an acyl group at its terminal nitrogen atom. gamma-Glutamyltyrosine is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. (HMDB0011741)

Age group comparisons
PMID	Age/Age interval, Gender	Value (unit of measurement)	Method	Sample
18384253	Age 24.5 ± 3, Gender ⚥	0.9 (mean value of the compound area)	LC-MS; GC-MS	plasma
18384253	Age 40.8 ± 5.6, Gender ⚥	0.83 (mean value of the compound area)	LC-MS; GC-MS	plasma
18384253	Age 55.6 ± 3.7, Gender ⚥	0.77 (mean value of the compound area)	LC-MS; GC-MS	plasma
27374292	Age [25–35] (median=32), Gender ♀ (Japanese)	0.693227 (average level of metabolite)	UHPLC-MS/MS Positive mode	serum
27374292	Age [55–65] (median=60), Gender ♀ (Japanese)	0.988538 (average level of metabolite)	UHPLC-MS/MS Positive mode	serum
27374292	Age [25–35] (median=32), Gender ♂ (Japanese)	0.918931 (average level of metabolite)	UHPLC-MS/MS Positive mode	serum
27374292	Age [55–64] (median=60), Gender ♂ (Japanese)	1.37054 (average level of metabolite)	UHPLC-MS/MS Positive mode	serum

Linear regression
PMID	Age/Age interval, Gender	Value (unit of measurement)	Method	Sample

log2 ratio/log2(FC)
PMID	Age/Age interval, Gender	Value (unit of measurement)	Method	Sample

Synonym:

gamma-Glu-Tyr
Chemical Formula:

C14H18N2O6
Exact Mass g/mol:

310.1160000
Systematic name:

(2S)-2-amino-5-[[(1S)-1-carboxy-2-(4-hydroxyphenyl)ethyl]amino]-5-oxopentanoic acid
SMILES:

C1=CC(=CC=C1C[C@@H](C(=O)O)NC(=O)CC[C@@H](C(=O)O)N)O
InChI:

InChI=1S/C14H18N2O6/c15-10(13(19)20)5-6-12(18)16-11(14(21)22)7-8-1-3-9(17)4-2-8/h1-4,10-11,17H,5-7,15H2,(H,16,18)(H,19,20)(H,21,22)/t10-,11-/m0/s1
InChI Key:

VVLXCWVSSLFQDS-QWRGUYRKSA-N
CAS number:

7432-23-7

Metabolite location:

Human organism, Body part, Human body biofluids, Biofluid tissues, Blood, Plasma, Tissue, Excreta material, Feces
Metabolite source:

Homo sapiens, endogenous metabolite

Age group comparisons

Method: LC-MS; GC-MS

Sample: plasma

PMID: 18384253

Age group comparisons

Method: UHPLC-MS/MS Positive mode

Sample: serum

PMID: 27374292