N-acetylglycine

Info Variations

view

Name: N-acetylglycine
Description: N-acetylglycine is used is in biological research of peptidomimetics. It is used as the blocking agent of the N-terminus to prepare unnatural and unusual amino acids and amino acid analogs as well ... as to modify peptides. N-Substituted glycine analogs are widely used in peptidomimetics and drug research. Excessive amounts N-acetyl amino acids including N-acetylglycine (as well as N-acetylserine, N-acetylglutamine, N-acetylglutamate, N-acetylalanine, Nacetylmethionine and smaller amounts of N-acetylthreonine, N-acetylleucine, N-acetylvaline and N-acetylisoleucine) can be detected in the urine with individuals with acylase I defiency, a genetic disorder. This enzyme is involved in the degradation of N-acylated proteins. Individuals with this disorder will experience convulsions, hearing loss ond difficulty feeding.

Age group comparisons
PMID	Age/Age interval, Gender	Value (unit of measurement)	Method	Sample

Linear regression
PMID	Age/Age interval, Gender	Value (unit of measurement)	Method	Sample
23838602	Age [17–85], Gender ⚥	0.014 (β)	UHPLC/MS/MS	serum + plasma

log2 ratio/log2(FC)
PMID	Age/Age interval, Gender	Value (unit of measurement)	Method	Sample

Synonym:

acetylglycocoll ; acetylglycine; ethanoylaminoethanoic acid; aceturic acid; acetylamino-acetic acid; acetamidoacetic acid;ac-gly-OH; acetylaminoacetic acid
Chemical Formula:

C4H7NO3
Exact Mass g/mol:

117.0425900
Systematic name:

glycine, N-acetyl-;N-acetylglycine
SMILES:

CC(=O)NCC(O)=O
InChI:

InChI=1S/C4H7NO3/c1-3(6)5-2-4(7)8/h2H2,1H3,(H,5,6)(H,7,8)
InChI Key:

OKJIRPAQVSHGFK-UHFFFAOYSA-N
CAS number:

543-24-8

Metabolite location:

Human organism, Body part, Human body biofluids, Biofluid tissues, Blood, Plasma, Serum, Saliva, Urine, Tissue, Cellular (general class), Subcellular, Cytoplasm, Excreta material
Metabolite source:

Homo sapiens, endogenous metabolite

Linear regression

Method: UHPLC/MS/MS

Sample: serum + plasma

PMID: 23838602

β = 0.014 (y = βx + α)

p-value < 0.05