etiocholanolone glucuronide

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  • Name: etiocholanolone glucuronide
  • Description: Etiocholanolone glucuronide is a natural human metabolite of etiocholanolone generated in the liver by UDPglucuonyltransferase. Etiocholanolone (or 5-isoandrosterone) is a metabolite of testosteron... e. Classified a ketosteroid, it causes fever, immunostimulation and leukocytosis. Glucuronidation is used to assist in the excretion of toxic substances, drugs or other substances that cannot be used as an energy source. Glucuronic acid is attached via a glycosidic bond to the substance, and the resulting glucuronide, which has a much higher water solubility than the original substance, is eventually excreted by the kidneys. (HMDB0004484)
Overview of age-variations
Age group comparisons
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
27374292 Age [25-35], Gender ♀ 1.156813 (average level of metabolite) LC/MS negative mode serum
27374292 Age [55-65], Gender ♀ 0.598496 (average level of metabolite) LC/MS negative mode serum
27374292 Age [25-35], Gender ♂ 1.847698 (average level of metabolite) LC/MS negative mode serum
27374292 Age [55-64], Gender ♂ 0.942656 (average level of metabolite) LC/MS negative mode serum
Linear regression
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
log2 ratio/log2(FC)
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
Summary
  • Chemical Formula:
    C25H38O8
  • Exact Mass g/mol:
    466.0000000
  • Systematic name:
    (2S,3S,4S,5R,6R)-6-[[(3R,5R,8R,9S,10S,13S,14S)-10,13-dimethyl-17-oxo-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-3-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid
  • SMILES:
    CC12CCC(CC1CCC3C2CCC4(C3CCC4=O)C)OC5C(C(C(C(O5)C(=O)O)O)O)O
  • InChI:
    InChI=1S/C25H38O8/c1-24-9-7-13(32-23-20(29)18(27)19(28)21(33-23)22(30)31)11-12(24)3-4-14-15-5-6-17(26)25(15,2)10-8-16(14)24/h12-16,18-21,23,27-29H,3-11H2,1-2H3,(H,30,31)/t12-,13-,14+,15+,16+,18+,19+,20-,21+,23-,24+,25+/m1/s1
  • InChI Key:
    VFUIRAVTUVCQTF-SDHZCXLISA-N
Related resources
Pathway info P = product of S = substrate of
Metabolite sources and localization
  • Metabolite location:
    Human organism, Body part, Extracellular, Human body biofluids, Biofluid tissues, Blood, Urine, Organ, Kidney, Liver, Tissue, Hepatic tissue, Cellular (general class), Subcellular, Cell membrane, Cytoplasm, Endoplasmic reticulum, Excreta material
  • Metabolite source:
    Homo sapiens, endogenous metabolite
Age-variations
Age group comparisons
Method: LC/MS negative mode
Sample: serum
PubMed PMID: 27374292
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