androstenedione

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  • Name: androstenedione
  • Description: A delta-4 19-carbon steroid that is produced not only in the testis, but also in the ovary and the adrenal cortex. Depending on the tissue type, androstenedione can serve as a precursor to testoste... rone as well as estrone and estradiol. It is the common precursor of male and female sex hormones. Some androstenedione is also secreted into the plasma, and may be converted in peripheral tissues to testosterone and estrogens. Androstenedione originates either from the conversion of dehydroepiandrosterone or from 17-hydroxyprogesterone. It is further converted to either testosterone or estrone. The production of adrenal androstenedione is governed by ACTH, while production of gonadal androstenedione is under control by gonadotropins (HMDB0000053)
Overview of age-variations
Age group comparisons
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
9253307 Age [20-30], Gender ♀ 3.7 (nM) chromatography serum
9253307 Age [50-60], Gender ♀ 1.4 (nM) chromatography serum
9253307 Age [20-30], Gender ♂ 3.5 (nM) chromatography serum
9253307 Age [70-80], Gender ♂ 1.7 (nM) chromatography serum
Linear regression
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
log2 ratio/log2(FC)
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
Summary
  • Synonym:
    4-dione
  • Chemical Formula:
    C19H26O2
  • Exact Mass g/mol:
    286.0000000
  • Systematic name:
    (8R,9S,10R,13S,14S)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione
  • SMILES:
    CC12CCC(=O)C=C1CCC3C2CCC4(C3CCC4=O)C
  • InChI:
    InChI=1S/C19H26O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-16H,3-10H2,1-2H3/t14-,15-,16-,18-,19-/m0/s1
  • InChI Key:
    AEMFNILZOJDQLW-QAGGRKNESA-N
Related resources
Pathway info P = product of S = substrate of
Metabolite sources and localization
  • Metabolite location:
    Human organism, Body part, Extracellular, Human body biofluids, Biofluid tissues, Blood, Serum, Cerebrospinal fluid, Urine, Organ, Gland, Adrenal gland, Adrenal cortex, Gonad, Testicle, Kidney, Liver, Muscle, Placenta, Prostate, Skin, Tissue, Adipose tissue, Connective tissue, Connective tissue cell, Fibroblast, Hepatic tissue, Cellular (general class), Subcellular, Cell membrane, Cytoplasm, Endoplasmic reticulum, Mitochondria, Excreta material
  • Metabolite source:
    Homo sapiens, endogenous metabolite
Age-variations
Age group comparisons
Method: chromatography
Sample: serum
PubMed PMID: 9253307
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