cortisone

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  • Name: cortisone
  • Description: Cortisone is a pregnane (21-carbon) steroid hormone. It is one of the main hormones released by the adrenal gland in response to stress. In chemical structure, it is a corticosteroid closely relate... d to cortisol. It is used to treat a variety of ailments and can be administered intravenously, orally, intra-articularly (into a joint), or transcutaneously. Cortisone suppresses the immune system, thus reducing inflammation and attendant pain and swelling at the site of the injury. Risks exist, in particular in the long-term use of cortisone.It was first described in 1949.(CHEBI ID: 16962)
Overview of age-variations
Age group comparisons
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
27374292 Age [25-35], Gender ♀ 1.160653 (average level of metabolite) LC/MS negative mode serum
27374292 Age [55-65], Gender ♀ 0.874466 (average level of metabolite) LC/MS negative mode serum
Linear regression
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
log2 ratio/log2(FC)
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
Summary
  • Synonym:
    Kendall's compund E; Wintersteriner's compund F; 11-dehydro-17-hydroxycorticosterone; Andreson; cortisal; Reichstein's substance fa; 17-hydroxy-11-dehydrocorticosterone
  • Chemical Formula:
    C21H28O5
  • Exact Mass g/mol:
    360.0000000
  • Systematic name:
    (8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-dione
  • SMILES:
    CC12CCC(=O)C=C1CCC3C2C(=O)CC4(C3CCC4(C(=O)CO)O)C
  • InChI:
    InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1
  • InChI Key:
    MFYSYFVPBJMHGN-ZPOLXVRWSA-N
Related resources
Pathway info P = product of S = substrate of
Metabolite sources and localization
  • Metabolite location:
    Human organism, Body part, Extracellular, Human body biofluids, Biofluid tissues, Blood, Serum, Urine, Organ, Gland, Adrenal gland, Adrenal cortex, Gonad, Testicle, Thyroid gland, Intestine, Kidney, Muscle, Placenta, Skin, Skin tissue, Epidermis, Tissue, Adipose tissue, Connective tissue, Connective tissue cell, Fibroblast, Hepatic tissue, Nervous tissue, Nervous tissue cells, Nerve cell, Subcellular level of nervous cells, Myelin sheath, Cellular (general class), Subcellular, Cell membrane, Cytoplasm, Endoplasmic reticulum, Excreta material
  • Metabolite source:
    Homo sapiens, endogenous metabolite
Age-variations
Age group comparisons
Method: LC/MS negative mode
Sample: serum
PubMed PMID: 27374292
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