scyllo-inositol

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  • Name: scyllo-inositol
  • Description: A stereoisomer of inositol and a plant sugar alcohol found most abundantly in coconut palm trees, with potential amyloid plaque formation inhibitory activity. Following oral administration, scyllit... ol crosses the blood brain barrier and inhibits amyloid beta plaque formation in the brain through as of yet unknown mechanism(s). This may lead to reduced disease progression and improvement in cognitive function in patients with Alzheimer disease. (NCI:C122987)
Overview of age-variations
Age group comparisons
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
15468140 Age [24-29], Gender ⚥ 0.3 (nM) H-MRS white matter
15468140 Age [46-71], Gender ⚥ 0.43 (nM) H-MRS white matter
23701591 Age [34-39], Gender ⚥ (American population) 1.0 (signal intensity) HNMR urine
23701591 Age [72-84], Gender ⚥ (American population) 1.25 (signal intensity) HNMR urine
27374292 Age [25–35] (median=32), Gender ♀ 0.825468 (mean value of the compound area) GC/MS serum
27374292 Age [55-65] (median=60), Gender ♀ 1.294049 (mean value of the compound area) GC/MS serum
Linear regression
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
log2 ratio/log2(FC)
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
Summary
  • Synonym:
    quercinitol;scyllitol; cocositol; ELND005; AZD-103
  • Chemical Formula:
    C6H12O6
  • Systematic name:
    cyclohexane-1,2,3,4,5,6-hexol
  • SMILES:
    C1(C(C(C(C(C1O)O)O)O)O)O
  • InChI:
    InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H
  • InChI Key:
    CDAISMWEOUEBRE-UHFFFAOYSA-N
Related resources
Pathway info P = product of S = substrate of
Metabolite sources and localization
  • Metabolite location:
    Human organism, Body part, Human body biofluids, Biofluid tissues, Blood, Serum, Cerebrospinal fluid, Saliva, Urine, Organ, Brain, Cerebral cortex, Motor cortex, White metter, Lateral ventricles, Corona radiata, Spinal cord, Tissue, Nervous tissue, Excreta material, Feces
  • Metabolite source:
    Homo sapiens, exogenous metabolite
Age-variations
Age group comparisons
Method: H-MRS
Sample: white matter
PubMed PMID: 15468140

Age group comparisons
Method: HNMR
Sample: urine
PubMed PMID: 23701591

Age group comparisons
Method: GC/MS
Sample: serum
PubMed PMID: 27374292