uric acid

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  • Name: uric acid
  • Description: Uric acid is the last product of purine metabolism in humans. The formation of uric acid is through the enzyme xanthineoxidase, which oxidizes oxypurines. Normally a small amount of uric acid is pr... esent in the body, but when there is an excess amount in the blood, called hyperuricemia, this can lead to gout and formation of kidney stones. As a therapeutic agent, it is known that uric acid is increased in response to oxidative stress, and as such, uric acid acts as an antioxidant. At present (August 2013), there is no approved formulation or indication for uric acid. In one country, Spain, uric acid is an investigational drug in a phase 3 trial studying its effects as an adjunct to alteplase in acute ischemic stroke. (DrugBank ID:DB08844)
Overview of age-variations
Age group comparisons
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
3780013 Age [15-19], Gender ♀ 2.73 (mmol/24 h) enzymatic analysis urine
3780013 Age [20-29], Gender ♀ 3.04 (mmol/24 h) enzymatic analysis urine
3780013 Age [30-39], Gender ♀ 2.9 (mmol/24 h) enzymatic analysis urine
3780013 Age [40-49], Gender ♀ 3.07 (mmol/24 h) enzymatic analysis urine
3780013 Age [50-59], Gender ♀ 3.08 (mmol/24 h) enzymatic analysis urine
3780013 Age [60+], Gender ♀ 1.94 (mmol/24 h) enzymatic analysis urine
3780013 Age [15-19], Gender ♂ 3.59 (mmol/24 h) enzymatic analysis urine
3780013 Age [20-29], Gender ♂ 4.15 (mmol/24 h) enzymatic analysis urine
3780013 Age [30-39], Gender ♂ 3.59 (mmol/24 h) enzymatic analysis urine
3780013 Age [40-49], Gender ♂ 3.86 (mmol/24 h) enzymatic analysis urine
3780013 Age [50-59], Gender ♂ 3.25 (mmol/24 h) enzymatic analysis urine
3780013 Age [60+], Gender ♂ 2.82 (mmol/24 h) enzymatic analysis urine
Linear regression
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
log2 ratio/log2(FC)
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
Summary
  • Synonym:
    lithic acid; 2,6,8-trioxypurine; 2,6,8-trioxopurine
  • Chemical Formula:
    C5H4N4O3
  • Exact Mass g/mol:
    168.0000000
  • Systematic name:
    7,9-dihydro-3H-purine-2,6,8-trione
  • SMILES:
    C12=C(NC(=O)N1)NC(=O)NC2=O
  • InChI:
    InChI=1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12)
  • InChI Key:
    LEHOTFFKMJEONL-UHFFFAOYSA-N
Related resources
Pathway info P = product of S = substrate of
Metabolite sources and localization
  • Metabolite source:
    Homo sapiens, endogenous metabolite
Age-variations
Age group comparisons
Method: enzymatic analysis
Sample: urine
PubMed PMID: 3780013