creatine

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  • Name: creatine
  • Description: Creatine is an amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Creatine is excreted as creatinine in the urine. Creatine f... unctions as part of the cell's energy shuttle. The high energy phosphate group of ATP is transferred to creatine to form phosphocreatine in the following reaction: Cr + ATP <-> PCr + ADP. This reaction is reversibly catalyzed by creatine kinase. In the human body, creatine is synthesized mainly in the liver by the use of parts from three different amino acids: arginine, glycine, and methionine. 95% of it is later stored in the skeletal muscles and the rest is stored in the brain, heart, and testes.(HMDB0000064)
Overview of age-variations
Age group comparisons
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
10331768 Age [20-60], Gender ⚥ 6.0 (mmol/l) MRI/MRS parietal white matter
10331768 Age [61-89], Gender ⚥ 6.5 (mmol/l) MRI/MRS parietal white matter
22081680 Age 24 ± 2.2, Gender ⚥ 0.25 (x10^(-3) mm^2/s) DW-MRS left centrum semiovale
22081680 Age 63 ± 7, Gender ⚥ 0.17 (x10^(-3) mm^2/s) DW-MRS left centrum semiovale
15708441 Age 26 ± 1, Gender ⚥ 6.63 (nM) H-MRS corona radiata
15708441 Age 54 ± 6, Gender ⚥ 7.33 (nM) H-MRS corona radiata
23701591 Age [34-39], Gender ⚥ (American population) 4.44 (signal intensity) HNMR urine
23701591 Age [72-84], Gender ⚥ (American population) 3.75 (signal intensity) HNMR urine
23701591 Age [54-57], Gender ⚥ (Taiwanese population) 6.44 (signal intensity) HNMR urine
23701591 Age [79-91], Gender ⚥ (Taiwanese population) 3.68 (signal intensity) HNMR urine
Linear regression
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
23838602 Age [17–85], Gender ⚥ 0.007 (β) UHPLC/MS/MS serum and plasma
23838602 Age [17–85], Gender ⚥ 1.43 (β) UHPLC/MS/MS serum and plasma
23838602 Age [17–85], Gender ⚥ 1.38 (β) UHPLC/MS/MS serum and plasma
23838602 Age [17–85], Gender ⚥ 1.02 (β) UHPLC/MS/MS serum and plasma
23709317 Age [20-39], Gender ⚥ 5.209 (β) magnetic resonance anterior cingulate cortex
23709317 Age [40-59], Gender ⚥ 5.841 (β) magnetic resonance anterior cingulate cortex
23709317 Age [60-89], Gender ⚥ 6.739 (β) magnetic resonance anterior cingulate cortex
23709317 Age [20-39], Gender ⚥ 6.038 (β) magnetic resonance posterior cingulate cortex
23709317 Age [40-59], Gender ⚥ 6.517 (β) magnetic resonance posterior cingulate cortex
23709317 Age [60-89], Gender ⚥ 7.011 (β) magnetic resonance posterior cingulate cortex
log2 ratio/log2(FC)
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
29090929 Age 42 ± 12, Gender ♀ -0.754 (log2 ratio) NMR blood
29090929 Age 41 ± 12, Gender ♂ -0.391 (log2 ratio) NMR blood
Summary
  • Synonym:
    N-methyl-N-guanylglycine; N-carbamimidoyl-N-methylglycine;methylguanidoacetate; (N-methylcarbamimidamido)acetate; methylguanidoacetic acid
  • Chemical Formula:
    C4H9N3O2
  • Systematic name:
    alpha-methylguanidino acetate; N-(aminoiminomethyl)-N-methyl-glycine;2-[carbamimidoyl(methyl)amino]acetic acid; 2-(N-methylcarbamimidamido)acetic acid; α-methylguanidino acetate
  • SMILES:
    CN(CC(=O)O)C(=N)N
  • InChI:
    InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9)
  • InChI Key:
    CVSVTCORWBXHQV-UHFFFAOYSA-N
  • CAS number:
    57-00-1
Pathway info P = product of S = substrate of
Metabolite sources and localization
  • Metabolite location:
    Human organism, Body part, Extracellular, Human body biofluids, Biofluid tissues, Blood, Blood cells, Platelet, Cerebrospinal fluid, Breast milk, Saliva, Sweat, Urine, Organ, Bladder, Brain, Cerebral cortex, Cingulate cortex, Anterior cingulate cortex, Posterior cingulate cortex, Lateral ventricles, Corona radiata, Gland, Gonad, Testicle, Heart, Intestine, Kidney, Muscle, Skeletal muscle, Placenta, Prostate, Skin, Skin tissue, Epidermis, Spleen, Tissue, Adipose tissue, Connective tissue, Connective tissue cell, Fibroblast, Nervous tissue, Nervous tissue cells, Nerve cell, Subcellular level of nervous cells, Myelin sheath, Cellular (general class), Subcellular, Cytoplasm, Mitochondria, Excreta material, Feces
  • Metabolite source:
    Homo sapiens, endogenous metabolite
Age-variations
Age group comparisons
Method: MRI/MRS
Sample: parietal white matter
PubMed PMID: 10331768

Age group comparisons
Method: DW-MRS
Sample: left centrum semiovale
PubMed PMID: 22081680

Age group comparisons
Method: H-MRS
Sample: corona radiata
PubMed PMID: 15708441

Age group comparisons
Method: HNMR
Sample: urine
PubMed PMID: 23701591

Linear regression
Method: UHPLC/MS/MS
Sample: serum and plasma
PubMed PMID: 23838602
β = 0.007 (y = βx + α)
p-value < 0.05

Linear regression
Method: UHPLC/MS/MS
Sample: serum and plasma
PubMed PMID: 23838602
β = 1.43 (y = βx + α)
p-value < 0.05

Linear regression
Method: UHPLC/MS/MS
Sample: serum and plasma
PubMed PMID: 23838602
β = 1.38 (y = βx + α)
p-value < 0.05

Linear regression
Method: UHPLC/MS/MS
Sample: serum and plasma
PubMed PMID: 23838602
β = 1.02 (y = βx + α)
p-value < 0.05

Linear regression
Method: magnetic resonance
Sample: anterior cingulate cortex
PubMed PMID: 23709317
β = 5.209 (y = βx + α)
p-value < 0.05

Linear regression
Method: magnetic resonance
Sample: anterior cingulate cortex
PubMed PMID: 23709317
β = 5.841 (y = βx + α)
p-value < 0.05

Linear regression
Method: magnetic resonance
Sample: anterior cingulate cortex
PubMed PMID: 23709317
β = 6.739 (y = βx + α)
p-value < 0.05

Linear regression
Method: magnetic resonance
Sample: posterior cingulate cortex
PubMed PMID: 23709317
β = 6.038 (y = βx + α)
p-value < 0.05

Linear regression
Method: magnetic resonance
Sample: posterior cingulate cortex
PubMed PMID: 23709317
β = 6.517 (y = βx + α)
p-value < 0.05

Linear regression
Method: magnetic resonance
Sample: posterior cingulate cortex
PubMed PMID: 23709317
β = 7.011 (y = βx + α)
p-value < 0.05

Fold-change with age
Method: NMR
Sample: blood
PubMed PMID: 29090929