NADP+

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  • Name: NADP+
  • Description: Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5-phosphate (NMN) coupled by pyrophosphate linkage to the 5-phosphate adenosine 2, 5-bisphosphate. It serves ... as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed. ) Hydrogen carrier in biochemical redox systems. In the hexose monophosphoric acid system it is reduced to Dihydrocoenzyme II and reoxidation in the presence of flavoproteins (Dictionary of Organic Compounds). This metabolite shows reduced levels in elderly healthy people's blood. Correlations with other metabolites (nad+) indicate that red blood cell redox metabolsim is declined in older people. (HMDB:HMDB0000217, PNAS April 19, 2016 113 (16) 4252-4259)
Overview of age-variations
Age group comparisons
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
27036001 Age 29 ± 4, Gender ⚥ 0.25 (CV (CV=SD of metabolite abundance (peak areas from LC-MS) divided by the mean)) LC-MS red blood cells, plasma, blood
27036001 Age 81 ± 7, Gender ⚥ 0.43 (CV (CV=SD of metabolite abundance (peak areas from LC-MS) divided by the mean)) LC-MS red blood cells, plasma, blood
Linear regression
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
log2 ratio/log2(FC)
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
Summary
  • Synonym:
    TPN; triphosphopyridine nucleotide; nicotinamide adenine dinucleotide phosphate; ;codehydrase II, beta-nicotinamide adenine dinucleotide phosphate; oxidized nicotinamide-adenine dinucleotide phosphate; Coenzyme II
  • Chemical Formula:
    C21H29N7O17P3+
  • Systematic name:
    [[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate; 2'-O-phosphonoadenosine 5'-{3-[1-(3-carbamoylpyridinio)-1,4-anhydro-D-ribitol-5-yl] dihydrogen diphosphate} ; 1-[(2R,3R,4S,5R)-5-[({[({[(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-3,4 dihydroxyoxolan-2-yl]-3-carbamoyl-1λ⁵-pyridin-1-ylium
  • SMILES:
    C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C4N=CN=C5N)OP(=O)(O)O)O)O)O)C(=O)N
  • InChI:
    InChI=1S/C21H28N7O17P3/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32/h1-4,7-8,10-11,13-16,20-21,29-31H,5-6H2,(H7-,22,23,24,25,32,33,34,35,36,37,38,39)/p+1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1
  • InChI Key:
    XJLXINKUBYWONI-NNYOXOHSSA-O
  • CAS number:
    53-59-8
Related resources
Pathway info P = product of S = substrate of
Metabolite sources and localization
  • Metabolite location:
    Human organism, Body part, Extracellular, Human body biofluids, Biofluid tissues, Blood, Tissue, All tissues, Cellular (general class), Subcellular, Endoplasmic reticulum, Mitochondria, Nucleus
  • Metabolite source:
    Homo sapiens, endogenous metabolite
Age-variations
Age group comparisons
Method: LC-MS
Sample: red blood cells; plasma; blood
PubMed PMID: 27036001