alpha-tocopherol

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  • Name: alpha-tocopherol
  • Description: alpha-Tocopherol is traditionally recognized as the most active form of vitamin E in humans and is a powerful biological antioxidant. The measurement of "vitamin E" activity in international units ... (IU) was based on fertility enhancement by the prevention of spontaneous abortions in pregnant rats relative to alpha-Tocopherol. Natural vitamin E exists in eight different forms or isomers: four tocopherols and four tocotrienols. In foods, the most abundant sources of vitamin E are vegetable oils such as palm oil, sunflower, corn, soybean, and olive oil. Nuts, sunflower seeds, and wheat germ are also good sources (Wikipedia).
Overview of age-variations
Age group comparisons
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
18384253 Age 24.5 ± 3, Gender ⚥ 0.91 (mean value of the compound area) LC-MS; GC-MS plasma
18384253 Age 40.8 ± 5.6, Gender ⚥ 0.95 (mean value of the compound area) LC-MS; GC-MS plasma
18384253 Age 55.6 ± 3.7, Gender ⚥ 1.11 (mean value of the compound area) LC-MS; GC-MS plasma
2619256 Age 27.4 ± 3.5, Gender ♀ 9.27 (mg/l) HPLC plasma
2619256 Age 75.4 ± 5.7, Gender ♀ 12.19 (mg/l) HPLC plasma
27374292 Age [25-35], Gender ♀ 0.930494 (average level of metabolite) GC/MS blood
27374292 Age [55-65], Gender ♀ 1.210213 (average level of metabolite) GC/MS blood
27374292 Age [25-35], Gender ♂ 0.966089 (average level of metabolite) GC/MS blood
27374292 Age [55-64], Gender ♂ 1.132492 (average level of metabolite) GC/MS blood
Linear regression
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
log2 ratio/log2(FC)
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
Summary
  • Synonym:
    E-307
  • Chemical Formula:
    C29H50O2
  • Exact Mass g/mol:
    430.3810000
  • Systematic name:
    (2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-ol
  • SMILES:
    CC1=C(C(=C2CC[C@@](OC2=C1C)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)C)O
  • InChI:
    InChI=1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3/t21-,22-,29-/m1/s1
  • InChI Key:
    GVJHHUAWPYXKBD-IEOSBIPESA-N
  • CAS number:
    1406-18-4
Related resources
Pathway info P = product of S = substrate of
Metabolite sources and localization
  • Metabolite location:
    Human organism, Body part, Extracellular, Human body biofluids, Biofluid tissues, Blood, Blood cells, Platelet, Red blood cell, Erythrocyte, White blood cell, Lymphocyte, Plasma, Cerebrospinal fluid, Breast milk, Saliva, Organ, Bladder, Gland, Gonad, Testicle, Intestine, Liver, Muscle, Skeletal muscle, Pancreas, Placenta, Prostate, Skin, Skin tissue, Epidermis, Stratum corneum, Spleen, Tissue, Adipose tissue, Connective tissue, Connective tissue cell, Fibroblast, Nervous tissue, Nervous tissue cells, Nerve cell, Neuron, Cellular (general class), Subcellular, Cell membrane, Cytoplasm, Excreta material, Feces
  • Metabolite source:
    Homo sapiens, exogenous metabolite
Age-variations
Age group comparisons
Method: LC-MS; GC-MS
Sample: plasma
PubMed PMID: 18384253
Age group comparisons
Method: HPLC
Sample: plasma
PubMed PMID: 2619256
Age group comparisons
Method: GC/MS
Sample: blood
PubMed PMID: 27374292
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