creatinine

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  • Name: creatinine
  • Description: Creatinine, or creatine anhydride, is a breakdown product of creatine phosphate in muscle. The loss of a water molecule from creatine results in the formation of creatinine. Creatinine is transferr... ed to the kidneys by blood plasma, whereupon it is eliminated from the body by glomerular filtration and partial tubular excretion. Creatinine is usually produced at a fairly constant rate by the body. Measuring serum creatinine is a simple test and it is the most commonly used indicator of renal function. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons. Therefore, this test is not suitable for detecting early kidney disease. The typical reference range for women is considered about 45-90 µmol/L; for men 60-110 µmol/L. Creatine and creatinine are metabolized in the kidneys, muscle, liver, and pancreas. (HMDB:HMDB0000562)
Overview of age-variations
Age group comparisons
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
24457528 Age 100.7 ± 2.1, Gender ⚥ 1.73 (mean of regulated metabolite) H-NMR serum
24457528 Age 70 ± 6, Gender ⚥ 1.44 (mean of regulated metabolite) H-NMR serum
24457528 Age 100.7 ± 2.1, Gender ♀ 1.71 (mean of regulated metabolite) H-NMR serum
24457528 Age 70 ± 6, Gender ♀ 1.44 (mean of regulated metabolite) H-NMR serum
24457528 Age 100.7 ± 2.1, Gender ♂ 1.79 (mean of regulated metabolite) H-NMR serum
24457528 Age 70 ± 6, Gender ♂ 1.54 (mean of regulated metabolite) H-NMR serum
23701591 Age [34-39], Gender ⚥ (American population) 28.29 (signal intensity) HNMR urine
23701591 Age [72-84], Gender ⚥ (American population) 22.46 (signal intensity) HNMR urine
3780013 Age [15-19], Gender ♀ 11.31 (mmol/24 h) Jaffe reaction urine
3780013 Age [20-29], Gender ♀ 10.56 (mmol/24 h) Jaffe reaction urine
3780013 Age [30-39], Gender ♀ 11.18 (mmol/24 h) Jaffe reaction urine
3780013 Age [40-49], Gender ♀ 11.5 (mmol/24 h) Jaffe reaction urine
3780013 Age [50-59], Gender ♀ 9.85 (mmol/24 h) Jaffe reaction urine
3780013 Age [60+], Gender ♀ 6.94 (mmol/24 h) Jaffe reaction urine
3780013 Age [15-19], Gender ♂ 15.53 (mmol/24 h) Jaffe reaction urine
3780013 Age [20-29], Gender ♂ 15.19 (mmol/24 h) Jaffe reaction urine
3780013 Age [30-39], Gender ♂ 15.47 (mmol/24 h) Jaffe reaction urine
3780013 Age [40-49], Gender ♂ 15.27 (mmol/24 h) Jaffe reaction urine
3780013 Age [50-59], Gender ♂ 13.33 (mmol/24 h) Jaffe reaction urine
3780013 Age [60+], Gender ♂ 13.39 (mmol/24 h) Jaffe reaction urine
299555 Age [18-23], Gender ♀ 1.37 (gm/day) nitrogen balance experiments urine
299555 Age [67-91], Gender ♀ 0.68 (gm/day) nitrogen balance experiments urine
299555 Age [20-25], Gender ♂ 1.99 (gm/day) nitrogen balance experiments urine
299555 Age [68-72], Gender ♂ 1.12 (gm/day) nitrogen balance experiments urine
Linear regression
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
23838602; 299555 Age [17–85], Gender ⚥ -0.009 (β) UHPLC/MS/MS serum and plasma
23838602 Age [17–85], Gender ⚥ -3.11 (β) UHPLC/MS/MS serum and plasma
23838602 Age [17–85], Gender ⚥ -2.69 (β) UHPLC/MS/MS serum and plasma
23838602 Age [17–85], Gender ⚥ -2.24 (β) UHPLC/MS/MS serum and plasma
log2 ratio/log2(FC)
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
Summary
  • Synonym:
    creatine anhydride;1-methylglycocyamidine; 1-methylhydantoin-2-imide
  • Chemical Formula:
    C4H7N3O
  • Systematic name:
    2-imino-1-methylimidazolidin-4-one; 2-amino-1-Methylimidazolin-4-one;2-amino-3-methyl-4H-imidazol-5-one
  • SMILES:
    CN1CC(=O)N=C1N
  • InChI:
    InChI=1S/C4H7N3O/c1-7-2-3(8)6-4(7)5/h2H2,1H3,(H2,5,6,8)
  • InChI Key:
    DDRJAANPRJIHGJ-UHFFFAOYSA-N
  • CAS number:
    60-27-5
Related resources
Pathway info P = product of S = substrate of
Metabolite sources and localization
  • Metabolite location:
    Human organism, Body part, Human body biofluids, Amniotic fluid, Biofluid tissues, Blood, Blood cells, Platelet, Cerebrospinal fluid, Breast milk, Saliva, Sweat, Urine, Organ, Bladder, Gland, Gonad, Testicle, Thyroid gland, Kidney, Liver, Muscle, Skeletal muscle, Pancreas, Placenta, Prostate, Spleen, Tissue, Adipose tissue, Connective tissue, Connective tissue cell, Fibroblast, Nervous tissue, Nervous tissue cells, Nerve cell, Cellular (general class), Subcellular, Cytoplasm, Excreta material, Feces
  • Metabolite source:
    Homo sapiens, endogenous metabolite
Age-variations
Age group comparisons
Method: H-NMR
Sample: serum
PubMed PMID: 24457528

Age group comparisons
Method: HNMR
Sample: urine
PubMed PMID: 23701591

Age group comparisons
Method: Jaffe reaction
Sample: urine
PubMed PMID: 3780013

Age group comparisons
Method: nitrogen balance experiments
Sample: urine
PubMed PMID: 299555
Linear regression
Method: UHPLC/MS/MS
Sample: serum and plasma
PubMed PMID: 23838602; 299555
β = -0.009 (y = βx + α)
p-value < 0.05

Linear regression
Method: UHPLC/MS/MS
Sample: serum and plasma
PubMed PMID: 23838602
β = -3.11 (y = βx + α)
p-value < 0.05

Linear regression
Method: UHPLC/MS/MS
Sample: serum and plasma
PubMed PMID: 23838602
β = -2.69 (y = βx + α)
p-value < 0.05

Linear regression
Method: UHPLC/MS/MS
Sample: serum and plasma
PubMed PMID: 23838602
β = -2.24 (y = βx + α)
p-value < 0.05