nicotinic acid

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  • Name: nicotinic acid
  • Description: Nicotinic acid, also known as niacin or vitamin B3, is a water-soluble vitamin whose derivatives such as NADH, NAD, NAD+, and NADP play essential roles in energy metabolism in the living cell and ... DNA repair. The designation vitamin B3 also includes the amide form, nicotinamide or niacinamide. Severe lack of niacin causes the deficiency disease pellagra, whereas a mild deficiency slows down the metabolism decreasing cold tolerance. The recommended daily allowance of niacin is 2-12 mg a day for children, 14 mg a day for women, 16 mg a day for men, and 18 mg a day for pregnant or breast-feeding women. It is found in various animal and plant tissues and has pellagra-curative, vasodilating, and antilipemic properties. The liver can synthesize niacin from the essential amino acid tryptophan (see below), but the synthesis is extremely slow and requires vitamin B6; 60 mg of tryptophan are required to make one milligram of niacin. Bacteria in the gut may also perform the conversion but are inefficient. (HMDB0001488)
Overview of age-variations
Age group comparisons
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
Linear regression
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
log2 ratio/log2(FC)
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
26088811 Age 40.9 ± 10.3, Gender ⚥ 5.3 (log2 ratio) UHPLC positive mode urine
Summary
  • Synonym:
    niacin; pyridine-3-carboxylic acid; 3-pyridinecarboxylic acid; 3-carboxypyridine
  • Chemical Formula:
    C6H5NO2
  • Exact Mass g/mol:
    123.0000000
  • Systematic name:
    pyridine-3-carboxylic acid
  • SMILES:
    C1=CC(=CN=C1)C(=O)O
  • InChI:
    InChI=1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
  • InChI Key:
    PVNIIMVLHYAWGP-UHFFFAOYSA-N
Pathway info P = product of S = substrate of
Metabolite sources and localization
  • Metabolite location:
    Human organism, Body part, Extracellular, Human body biofluids, Biofluid tissues, Blood, Cerebrospinal fluid, Saliva, Urine, Organ, Intestine, Kidney, Liver, Muscle, Skeletal muscle, Skin, Skin tissue, Epidermis, Tissue, Adipose tissue, Connective tissue, Connective tissue cell, Fibroblast, Cellular (general class), Subcellular, Cytoplasm, Excreta material, Feces
  • Metabolite source:
    Homo sapiens, endogenous metabolite
Age-variations
Fold-change with age
Method: UHPLC positive mode
Sample: urine
PubMed PMID: 26088811