arginine

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  • Name: arginine
  • Description: Arginine, a semiessential or conditionally essential amino acid in humans, is one of the most metabolically versatile amino acids and serves as a precursor for the synthesis of urea, nitric oxide, ... polyamines, proline, glutamate, creatine, and agmatine. Arginine is metabolized through a complex and highly regulated set of pathways that remain incompletely understood at both the whole-body and the cellular levels. Adding to the metabolic complexity is the fact that limited arginine availability can selectively affect the expression of specific genes, most of which are themselves involved in some aspect of arginine metabolism. (PMID:16470022)
Overview of age-variations
Age group comparisons
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
12768504 Age 32.6 ± 4.4 , Gender ♀ 110.0 (μmol/l) LC blood
12768504 Age 48 ± 4.3, Gender ♀ 99.0 (μmol/l) LC blood
12768504 Age 74.7 ± 10, Gender ♀ 106.0 (μmol/l) LC blood
12768504 Age 33.3 ± 3.8, Gender ♂ 131.0 (μmol/l) LC blood
12768504 Age 48.4 ± 6, Gender ♂ 128.0 (μmol/l) LC blood
12768504 Age 75.9 ± 9.3, Gender ♂ 118.0 (μmol/l) LC blood
30113646 Age 44.6 ± 14, Gender ♀ (Dutch) 72.8 (μmol/L) LC-MS/MS plasma
30113646 Age 44.6 ± 13, Gender ♀ (South Asian Surinamese) 78.1 (μmol/L) LC-MS/MS plasma
30113646 Age 44.6 ± 14, Gender ♀ (Dutch) 104.1 (% (percentage of metabolite concentration compared with baseline (100%) per 10 year increment in age; analyses were adjusted for BMI)) LC-MS/MS plasma
30113646 Age 44.6 ± 13, Gender ♀ (South Asian Surinamese) 104.7 (% (percentage of metabolite concentration compared with baseline (100%) per 10 year increment in age; analyses were adjusted for BMI)) LC-MS/MS plasma
Linear regression
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
30841604 Age [25-74], Gender ♀ -0.1 (β) indirect potentiometry serum
30841604 Age [45-80], Gender ♀ -0.06 (β) FIA-ESI-MS/MS serum
30841604 Age [25-74], Gender ♂ -0.12 (β) indirect potentiometry serum
30841604 Age [45-80], Gender ♂ -0.07 (β) FIA-ESI-MS/MS serum
log2 ratio/log2(FC)
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
Summary
  • Synonym:
    Arg;2-amino-5-guanidinopentanoic acid; R; 2-amino-5-guanidinovaleric acid; 2-amino-5-(carbamimidamido)pentanoic acid
  • Chemical Formula:
    C6H14N4O2
  • Exact Mass g/mol:
    174.1116760
  • Systematic name:
    2-amino-5-(diaminomethylideneamino)pentanoic acid;(2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid
  • SMILES:
    C(CC(C(=O)O)N)CN=C(N)N
  • InChI:
    InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1
  • InChI Key:
    ODKSFYDXXFIFQN-BYPYZUCNSA-N
Related resources
Pathway info P = product of S = substrate of
Metabolite sources and localization
  • Metabolite location:
    Human organism, Body part, Human body biofluids, Biofluid tissues, Blood, Plasma, Cerebrospinal fluid, Saliva, Sweat, Urine, Tissue, Excreta material
  • Metabolite source:
    Homo sapiens, endogenous metabolite
Age-variations
Age group comparisons
Method: LC
Sample: blood
PubMed PMID: 12768504

Age group comparisons
Method: LC-MS/MS
Sample: plasma
PubMed PMID: 30113646

Age group comparisons
Method: LC-MS/MS
Sample: plasma
PubMed PMID: 30113646

Linear regression
Method: indirect potentiometry
Sample: serum
PubMed PMID: 30841604
β = -0.1 (y = βx + α)
p-value < 0.05

Linear regression
Method: FIA-ESI-MS/MS
Sample: serum
PubMed PMID: 30841604
β = -0.06 (y = βx + α)
p-value < 0.05

Linear regression
Method: indirect potentiometry
Sample: serum
PubMed PMID: 30841604
β = -0.12 (y = βx + α)
p-value < 0.05

Linear regression
Method: FIA-ESI-MS/MS
Sample: serum
PubMed PMID: 30841604
β = -0.07 (y = βx + α)
p-value < 0.05