hypoxanthine
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Name: hypoxanthine
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Description: Hypoxanthine is a naturally occurring purine derivative and a reaction intermediate in the metabolism of adenosine and in the formation of nucleic acids by the salvage pathway. Hypoxanthine is also...
Overview of age-variations
| Age group comparisons | ||||
|---|---|---|---|---|
| PMID | Age/Age interval, Gender | Value (unit of measurement) | Method | Sample |
| 18384253 | Age 24.5 ± 3, Gender ⚥ | 0.41 (mean value of the compound area) | LC-MS; GC-MS | plasma |
| 18384253 | Age 40.8 ± 5.6, Gender ⚥ | 0.84 (mean value of the compound area) | LC-MS; GC-MS | plasma |
| 18384253 | Age 55.6 ± 3.7, Gender ⚥ | 1.36 (mean value of the compound area) | LC-MS; GC-MS | plasma |
| 27374292 | Age [25-35], Gender ♂ | 1.20134 (average level of metabolite) | LC/MS negative mode | serum |
| 27374292 | Age [55-64], Gender ♂ | 0.961407 (average level of metabolite) | LC/MS negative mode | serum |
| Linear regression | ||||
|---|---|---|---|---|
| PMID | Age/Age interval, Gender | Value (unit of measurement) | Method | Sample |
| log2 ratio/log2(FC) | ||||
|---|---|---|---|---|
| PMID | Age/Age interval, Gender | Value (unit of measurement) | Method | Sample |
Summary
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Synonym:purine-6-ol
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Chemical Formula:C5H4N4O
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Exact Mass g/mol:136.0390000
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Systematic name:3,7-dihydropurin-6-one
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SMILES:C1=NC2=C(N1)C(=O)N=CN2
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InChI:InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)
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InChI Key:FDGQSTZJBFJUBT-UHFFFAOYSA-N
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CAS number:68-94-0
Related resources
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Literature sources:
- Lawton KA et al., Analysis of the adult human plasma metabolome., Pharmacogenomics, 383-97, 2008
- Saito K et al., Gender- and Age-Associated Differences in Serum Metabolite Profiles among Japanese Populations., Biological & pharmaceutical bulletin, 1179-86, 2016
Pathway info P = product of S = substrate of
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Metabolic pathways other metabolites from MetaboAge1,7-dimethyluric acid 1-methylnicotinamide 1-methylxanthine 11,12-dihydroxy-eicosatrienoic acid 4-acetamidobutanoate 4-hydroxybenzoic acid 4-hydroxyphenylacetate 4-methyl-2-oxopentanoate D-glucose D-glucuronate D-mannitol D-mannose D-ribose D-sorbitol D-xylose Dihydroxymandelic acid (DHMA) L-citrulline L-threonine N-acetylneuraminate N-acetylornithine N-methyl-4-pyridone-3-carboxamide N6-acetyl-lysine NAD+ NADP+ Norepinephrine UDP-acetyl-glucosamine Vanillylmandelic acid (VMA) acetone acetylphenylalanine alpha-tocopherol androstenedione arachidonic acid arginine beta-hydroxyisovalerate beta-tocopherol betaine caffeine campesterol carnosine cholesterol choline choline phosphate citric acid cortisone creatine creatinine dehydroepiandrosterone dimethyl sulfone dimethylamine dimethylglycine fumaric acid gamma-tocopherol glutarate glutathione glycine guanidinoacetic acid gulonic acid homovanillate (HVA) inosine inositol 1-phosphate kynurenic acid leukotriene E4 linoleic acid myo-inositol niacinamide nicotinic acid normetanephrine oxalic acid p-hydroxyphenylacetic acid paraxanthine phenylglyoxylic acid pregnelone propylene glycol pyridoxic acid pyruvate quinic acid scyllo-inositol sphingosine 1-phosphate taurine theobromine trans-4-hydroxyproline trimethylamine N-oxide tryptamine urate urea uric acid uridine vanillylmandelate (VMA) xanthine
Metabolite sources and localization
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Metabolite location:Human organism, Body part, Extracellular, Human body biofluids, Biofluid tissues, Blood, Blood cells, Platelet, Plasma, Serum, Cerebrospinal fluid, Breast milk, Saliva, Urine, Organ, Gland, Gonad, Testicle, Intestine, Kidney, Liver, Muscle, Skeletal muscle, Placenta, Prostate, Skin, Skin tissue, Epidermis, Spleen, Tissue, Adipose tissue, Connective tissue, Connective tissue cell, Fibroblast, Cellular (general class), Subcellular, Cytoplasm, Lysosome, Peroxisome, Excreta material, Feces
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Metabolite source:Homo sapiens, endogenous metabolite