myo-inositol

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  • Name: myo-inositol
  • Description: An inositol having myo- configuration. Myo-inositol is a carbocyclic sugar that is abundant in brain and other mammalian tissues, mediates cell signal transduction in response to a variety of hormo... nes, neurotransmitters and growth factors and participates in osmoregulation. It is a sugar alcohol with half the sweetness of sucrose (table sugar). It is made naturally in humans from glucose. Each kidney makes 2g a day; so 4g a day total is made. Other tissues synthesize it too, and the highest concentration is in the brain where it plays an important role making other neurotransmitters, and some steroid hormones bind to their receptors. (CHEBI:17268, https://en.wikipedia.org/wiki/Inositol)
Overview of age-variations
Age group comparisons
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
18384253 Age 24.5 ± 3, Gender ⚥ 0.83 (mean value of the compound area) LC-MS; GC-MS plasma
18384253 Age 40.8 ± 5.6, Gender ⚥ 1.09 (mean value of the compound area) LC-MS; GC-MS plasma
18384253 Age 55.6 ± 3.7, Gender ⚥ 1.18 (mean value of the compound area) LC-MS; GC-MS plasma
15468140 Age [24-29], Gender ⚥ 3.93 (nM) H-MRS white matter
15468140 Age [46-71], Gender ⚥ 4.69 (nM) H-MRS white matter
15708441 Age 26 ± 1, Gender ⚥ 4.24 (nM) H-MRS corona radiata
15708441 Age 54 ± 6, Gender ⚥ 4.96 (nM) H-MRS corona radiata
15708441 Age 26 ± 1, Gender ⚥ 4.15 (nM) H-MRS motor cortex
15708441 Age 54 ± 6, Gender ⚥ 5.2 (nM) H-MRS motor cortex
27374292 Age [25-35] (median=32), Gender ♀ 0.860393 (mean value of the compound area) LC/MS HILIC serum
27374292 Age [55-65] (median=60), Gender ♀ 1.158801 (mean value of the compound area) LC/MS HILIC serum
Linear regression
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
8637436 Age [19-78], Gender ⚥ 0.42 (β) MRI/ HMRS right-frontal white matter
8637436 Age [19-78], Gender ⚥ 0.7 (β) MRI/ HMRS mid-frontal gray matter
log2 ratio/log2(FC)
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
Summary
  • Chemical Formula:
    C6H12O6
  • Systematic name:
    (1r,2R,3S,4s,5R,6S)-cyclohexane-1,2,3,4,5,6-hexol
  • SMILES:
    O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O
  • InChI:
    InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6-
  • InChI Key:
    CDAISMWEOUEBRE-GPIVLXJGSA-N
  • CAS number:
    87-89-8
Related resources
Pathway info P = product of S = substrate of
Metabolite sources and localization
  • Metabolite location:
    Human organism, Body part, Human body biofluids, Biofluid tissues, Blood, Plasma, Cerebrospinal fluid, Breast milk, Saliva, Sweat, Urine, Organ, Brain, Basal ganglia, Cerebral cortex, Motor cortex, White metter, Lateral ventricles, Corona radiata, Gland, Gonad, Testicle, Intestine, Kidney, Prostate, Spinal cord, Tissue, Connective tissue, Connective tissue cell, Fibroblast, Nervous tissue, Nervous tissue cells, Nerve cell, Neuron, Subcellular level of nervous cells, Myelin sheath, Excreta material, Feces
  • Metabolite source:
    Homo sapiens, endogenous metabolite
Age-variations
Age group comparisons
Method: LC-MS; GC-MS
Sample: plasma
PubMed PMID: 18384253
Age group comparisons
Method: H-MRS
Sample: white matter
PubMed PMID: 15468140
Age group comparisons
Method: H-MRS
Sample: corona radiata
PubMed PMID: 15708441
Age group comparisons
Method: H-MRS
Sample: motor cortex
PubMed PMID: 15708441
Age group comparisons
Method: LC/MS HILIC
Sample: serum
PubMed PMID: 27374292
Linear regression
Method: MRI/ HMRS
Sample: right-frontal white matter
PubMed PMID: 8637436
β = 0.42 (y = βx + α)
p-value < 0.05
Linear regression
Method: MRI/ HMRS
Sample: mid-frontal gray matter
PubMed PMID: 8637436
β = 0.7 (y = βx + α)
p-value < 0.05
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