NAD+

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  • Name: NAD+
  • Description: Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in all living cells. It serves both as a critical coenzyme for enzymes that fuel reduction-oxidation reactions, carrying electrons from ... one reaction to another, and as a cosubstrate for other enzymes such as the sirtuins and poly(adenosine diphosphate–ribose) polymerases. Cellular NAD+ concentrations change during aging, and modulation of NAD+ usage or production can prolong both health span and life span. The oxidised form of nicotinamide adenine dinucleotide found in all living cells. In metabolism, NAD+ is involved in redox reactions, carrying electrons from one reaction to another. (Science. 2015 Dec 4;350(6265):1208-13, CHEBI:15846)
Overview of age-variations
Age group comparisons
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
27036001 Age 29 ± 4, Gender ⚥ 0.29 (CV (CV=SD of metabolite abundance (peak areas from LC-MS) divided by the mean)) LC-MS blood
27036001 Age 81 ± 7, Gender ⚥ 0.27 (CV (CV=SD of metabolite abundance (peak areas from LC-MS) divided by the mean)) LC-MS blood
22848760 Age [0-1], Gender ⚥ 8.54 (ng NAD+/ mg protein) spectrophotometry skin tissue
22848760 Age [30-50], Gender ⚥ 2.74 (ng NAD+/ mg protein) spectrophotometry skin tissue
22848760 Age [51-70], Gender ⚥ 1.08 (ng NAD+/ mg protein) spectrophotometry skin tissue
22848760 Age [71-77], Gender ⚥ 1.06 (ng NAD+/ mg protein) spectrophotometry skin tissue
Linear regression
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
log2 ratio/log2(FC)
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
Summary
  • Synonym:
    adenosine 5'-{3-[1-(3-carbamoylpyridinio)-1,4-anhydro-D-ribitol-5-yl] dihydrogen diphosphate}; ; NAD;nadide; nicotinamide adenine dinucleotide
  • Chemical Formula:
    C21H28N7O14P2+
  • Systematic name:
    [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate; 1-[(2R,3R,4S,5R)-5-[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1λ⁵-pyridin-1-ylium
  • SMILES:
    C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C4N=CN=C5N)O)O)O)O)C(=O)N
  • InChI:
    InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p+1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1
  • InChI Key:
    BAWFJGJZGIEFAR-NNYOXOHSSA-O
  • CAS number:
    53-84-9
Related resources
Pathway info P = product of S = substrate of
Metabolite sources and localization
  • Metabolite location:
    Human organism, Body part, Human body biofluids, Biofluid tissues, Blood, Blood cells, Platelet, Organ, Brain, Gland, Adrenal gland, Liver, Muscle, Skeletal muscle, Prostate, Skin, Skin tissue, Epidermis, Tissue, Connective tissue, Connective tissue cell, Fibroblast, Cellular (general class), Subcellular, Cytoplasm, Endoplasmic reticulum, Mitochondria, Nucleus, Peroxisome
  • Metabolite source:
    Homo sapiens, endogenous metabolite
Age-variations
Age group comparisons
Method: LC-MS
Sample: blood
PubMed PMID: 27036001
Age group comparisons
Method: spectrophotometry
Sample: skin tissue
PubMed PMID: 22848760
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