D-mannose

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  • Name: D-mannose
  • Description: D-mannose is a carbohydrate. High-mannose-type oligosaccharides have been shown to play important roles in protein quality control. Several intracellular proteins, such as lectins, chaperones and g... lycan-processing enzymes, are involved in this process. These include calnexin/calreticulin, UDP-glucose:glycoprotein glucosyltransferase (UGGT), cargo receptors (such as VIP36 and ERGIC-53), mannosidase-like proteins (e.g. EDEM and Htm1p) and ubiquitin ligase (Fbs). They are thought to recognize high-mannose-type glycans with subtly different structures. Mannose-binding lectin (MBL) is an important constituent of the innate immune system. This protein binds through multiple lectin domains to the repeating sugar arrays that decorate many microbial surfaces, and is then able to activate the complement system through a specific protease called MBL-associated protease-2. The primary pathway for the formation of L-fucose in procaryotic and eucaryotic cells is from D-mannose via an internal oxidation reduction and then epimerization of GDP-D-mannose to produce GDP-L-fucose. This compound class represents a reducing sugar that exists in solution in multiple configurations. (PMID: 9488699, PMID:16154739, PMID:11414367).
Overview of age-variations
Age group comparisons
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
18384253 Age 24.5 ± 3, Gender ⚥ 1.02 (mean value of the compound area) LC-MS; GC-MS plasma
18384253 Age 40.8 ± 5.6, Gender ⚥ 1.06 (mean value of the compound area) LC-MS; GC-MS plasma
18384253 Age 55.6 ± 3.7, Gender ⚥ 0.91 (mean value of the compound area) LC-MS; GC-MS plasma
27374292 Age [25–35] (median=32), Gender ♀ (Japanese) 1.072535 (average level of metabolite) UHPLC-MS/MS HILIC serum
27374292 Age [55–65] (median=60), Gender ♀ (Japanese) 0.931593 (average level of metabolite) UHPLC-MS/MS HILIC serum
Linear regression
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
23838602 Age [17–85], Gender ⚥ 0.015 (β) UPLC-MS/MS; GC-MS serum, plasma
log2 ratio/log2(FC)
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
Summary
  • Synonym:
    D-mannopyranose
  • Chemical Formula:
    C6H12O6
  • Exact Mass g/mol:
    180.0630000
  • Systematic name:
    (3S,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol
  • SMILES:
    C([C@@H]1[C@H]([C@@H]([C@@H](C(O1)O)O)O)O)O
  • InChI:
    InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6?/m1/s1
  • InChI Key:
    WQZGKKKJIJFFOK-QTVWNMPRSA-N
  • CAS number:
    530-26-7;3458-28-4
Related resources
Pathway info P = product of S = substrate of
Metabolite sources and localization
  • Metabolite location:
    Human organism, Body part, Extracellular, Human body biofluids, Biofluid tissues, Blood, Plasma, Serum, Cerebrospinal fluid, Breast milk, Saliva, Urine, Organ, Bladder, Gland, Adrenal gland, Adrenal medulla, Gonad, Testicle, Intestine, Kidney, Muscle, Pancreas, Placenta, Skin, Skin tissue, Epidermis, Spleen, Tissue, Connective tissue, Connective tissue cell, Fibroblast, Nervous tissue, Nervous tissue cells, Subcellular level of nervous cells, Myelin sheath, Cellular (general class), Subcellular, Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Lysosome, Excreta material, Feces
  • Metabolite source:
    Homo sapiens, endogenous metabolite
Age-variations
Age group comparisons
Method: LC-MS; GC-MS
Sample: plasma
PubMed PMID: 18384253
Age group comparisons
Method: UHPLC-MS/MS HILIC
Sample: serum
PubMed PMID: 27374292
Linear regression
Method: UPLC-MS/MS; GC-MS
Sample: serum; plasma
PubMed PMID: 23838602
β = 0.015 (y = βx + α)
p-value < 0.05
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