glycine

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  • Name: glycine
  • Description: An unspecified stereoisomerism form of glycine (symbol Gly or G; ) which is the amino acid that has a single hydrogen atom as its side chain. It is the simplest possible amino acid. The chemical fo... rmula of glycine is NH2‐CH2‐COOH. Glycine is one of the proteinogenic amino acids. It is encoded by all the codons starting with GG (GGU, GGC, GGA, GGG). Glycine is a colorless, sweet-tasting crystalline solid. It is the only achiral proteinogenic amino acid. It can fit into hydrophilic or hydrophobic environments, due to its minimal side chain of only one hydrogen atom. The acyl radical is glycyl. (https://en.wikipedia.org/wiki/Glycine).
Overview of age-variations
Age group comparisons
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
18384253 Age 24.5 ± 3, Gender ⚥ 0.67 (mean value of the compound area) LC-MS; GC-MS plasma
18384253 Age 40.8 ± 5.6, Gender ⚥ 1.02 (mean value of the compound area) LC-MS; GC-MS plasma
18384253 Age 55.6 ± 3.7, Gender ⚥ 1.5 (mean value of the compound area) LC-MS; GC-MS plasma
17474139 Age 36.6 ± 5.5, Gender ⚥ 153.2 (mmol/mol ) H-NMR urine
17474139 Age 54.5 ± 7.6, Gender ⚥ 163.9 (mmol/mol ) H-NMR urine
23701591 Age [34-39], Gender ⚥ (American population) 5.24 (signal intensity) HNMR urine
23701591 Age [72-84], Gender ⚥ (American population) 3.31 (signal intensity) HNMR urine
30113646 Age 44.6 ± 14, Gender ♀ (Dutch) 158.0 (μmol/L (baseline)) LC-MS/MS plasma
30113646 Age 44.6 ± 14, Gender ♀ (Dutch) 110.8 (% (percentage of metabolite concentration compared with baseline (100%) per 10 year increment in age; analyses were adjusted for BMI)) LC-MS/MS plasma
Linear regression
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
log2 ratio/log2(FC)
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
29090929 Age 42 ± 12, Gender ♀ -0.258 (log2 ratio) NMR blood
29090929 Age 41 ± 12, Gender ♂ 0.067 (log2 ratio) NMR blood
Summary
  • Synonym:
    Gly
  • Chemical Formula:
    C2H5NO2
  • Exact Mass g/mol:
    75.0320000
  • Systematic name:
    2-aminoacetic acid
  • SMILES:
    C(C(=O)O)N
  • InChI:
    InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
  • InChI Key:
    DHMQDGOQFOQNFH-UHFFFAOYSA-N
  • CAS number:
    56-40-6
Related resources
Pathway info P = product of S = substrate of
Metabolite sources and localization
  • Metabolite location:
    Human organism, Body part, Human body biofluids, Biofluid tissues, Blood, Blood cells, Platelet, Plasma, Urine, Organ, Bladder, Brain, Gland, Thyroid gland, Intestine, Kidney, Pancreas, Placenta, Skin, Skin tissue, Epidermis, Stratum corneum, Spleen, Tissue, Connective tissue, Connective tissue cell, Fibroblast, Nervous tissue, Nervous tissue cells, Nerve cell, Neuron, Subcellular level of nervous cells, Myelin sheath, Excreta material
  • Metabolite source:
    Homo sapiens, endogenous metabolite
Age-variations
Age group comparisons
Method: LC-MS; GC-MS
Sample: plasma
PubMed PMID: 18384253
Age group comparisons
Method: H-NMR
Sample: urine
PubMed PMID: 17474139
Age group comparisons
Method: HNMR
Sample: urine
PubMed PMID: 23701591
Age group comparisons
Method: LC-MS/MS
Sample: plasma
PubMed PMID: 30113646
Age group comparisons
Method: LC-MS/MS
Sample: plasma
PubMed PMID: 30113646
Fold-change with age
Method: NMR
Sample: blood
PubMed PMID: 29090929
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