fumaric acid
-
Name: fumaric acid
-
Description: Fumaric acid is a butenedioic acid in which the C=C double bond has E geometry. It is an intermediate metabolite in the citric acid cycle. It has a role as a food acidity regulator and a fundamenta...
Overview of age-variations
| Age group comparisons | ||||
|---|---|---|---|---|
| PMID | Age/Age interval, Gender | Value (unit of measurement) | Method | Sample |
| Linear regression | ||||
|---|---|---|---|---|
| PMID | Age/Age interval, Gender | Value (unit of measurement) | Method | Sample |
| log2 ratio/log2(FC) | ||||
|---|---|---|---|---|
| PMID | Age/Age interval, Gender | Value (unit of measurement) | Method | Sample |
| 26088811 | Age 40.9 ± 10.3, Gender ⚥ | 1.8 (log2 ratio) | UHPLC negative mode | urine |
Summary
-
Synonym:2-butenedioic acid; allomaleic acid
-
Chemical Formula:C4H4O4
-
Exact Mass g/mol:116.0000000
-
Systematic name:(E)-but-2-enedioic acid
-
SMILES:C(=CC(=O)O)C(=O)O
-
InChI:InChI=1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1+
-
InChI Key:VZCYOOQTPOCHFL-OWOJBTEDSA-N
Related resources
-
Literature sources:
- Thévenot EA et al., Analysis of the Human Adult Urinary Metabolome Variations with Age, Body Mass Index, and Gender by Implementing a Comprehensive Workflow for Univariate and OPLS Statistical Analyses., Journal of proteome research, 3322-35, 2015
Pathway info P = product of S = substrate of
-
Tyrosine metabolism P other metabolites from MetaboAge4-hydroxyphenylacetate Norepinephrine Vanillylmandelic acid (VMA) homovanillate (HVA) normetanephrine p-hydroxyphenylacetic acid pyruvate vanillylmandelate (VMA)
Nicotinate and nicotinamide metabolism S other metabolites from MetaboAge1-methylnicotinamide N-methyl-4-pyridone-3-carboxamide NAD+ NADP+ niacinamide nicotinic acid pyruvate
Metabolic pathways other metabolites from MetaboAge1,7-dimethyluric acid 1-methylnicotinamide 1-methylxanthine 11,12-dihydroxy-eicosatrienoic acid 4-acetamidobutanoate 4-hydroxybenzoic acid 4-hydroxyphenylacetate 4-methyl-2-oxopentanoate D-glucose D-glucuronate D-mannitol D-mannose D-ribose D-sorbitol D-xylose Dihydroxymandelic acid (DHMA) L-citrulline L-threonine N-acetylneuraminate N-acetylornithine N-methyl-4-pyridone-3-carboxamide N6-acetyl-lysine NAD+ NADP+ Norepinephrine UDP-acetyl-glucosamine Vanillylmandelic acid (VMA) acetone acetylphenylalanine alpha-tocopherol androstenedione arachidonic acid arginine beta-hydroxyisovalerate beta-tocopherol betaine caffeine campesterol carnosine cholesterol choline choline phosphate citric acid cortisone creatine creatinine dehydroepiandrosterone dimethyl sulfone dimethylamine dimethylglycine gamma-tocopherol glutarate glutathione glycine guanidinoacetic acid gulonic acid homovanillate (HVA) hypoxanthine inosine inositol 1-phosphate kynurenic acid leukotriene E4 linoleic acid myo-inositol niacinamide nicotinic acid normetanephrine oxalic acid p-hydroxyphenylacetic acid paraxanthine phenylglyoxylic acid pregnelone propylene glycol pyridoxic acid pyruvate quinic acid scyllo-inositol sphingosine 1-phosphate taurine theobromine trans-4-hydroxyproline trimethylamine N-oxide tryptamine urate urea uric acid uridine vanillylmandelate (VMA) xanthine
Metabolite sources and localization
-
Metabolite location:Human organism, Body part, Extracellular, Human body biofluids, Biofluid tissues, Blood, Cerebrospinal fluid, Breast milk, Saliva, Sweat, Urine, Organ, Prostate, Tissue, Cellular (general class), Subcellular, Cell membrane, Cytoplasm, Mitochondria, Excreta material, Feces
-
Metabolite source:Homo sapiens, endogenous metabolite