N-acetylornithine

Info Variations

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Name: N-acetylornithine
Description: An N2-acyl-L-ornithine where the acyl group is specified to be acetyl. N-acetylornithine is a minor component of deproteinized blood plasma of human blood. Human blood plasma contains a variable am... ount of acetylornithine, averaging 1.1 +/- 0.4 mumol/L (range 0.8-0.2 mumol/L). Urine contains a very small amount of acetylornithine, approximately 1 nmol/mg creatinine (1 mumol/day) (PMID:508804; CHEBI:16543)

Overview of age-variations

Age group comparisons
PMID	Age/Age interval, Gender	Value (unit of measurement)	Method	Sample

Linear regression
PMID	Age/Age interval, Gender	Value (unit of measurement)	Method	Sample
23838602	Age [17–85], Gender ⚥	0.006 (β)	UHPLC/MS/MS	serum + plasma

log2 ratio/log2(FC)
PMID	Age/Age interval, Gender	Value (unit of measurement)	Method	Sample

Summary

Synonym:

N-acetyl-L-ornithine; N-alpha-acetylornithine
Chemical Formula:

C7H14N2O3
Exact Mass g/mol:

174.1000000
Systematic name:

(2S)-2-acetamido-5-aminopentanoic acid; N2-acetyl-L-ornithine
SMILES:

CC(=O)N[C@@H](CCCN)C(=O)O
InChI:

InChI=1S/C7H14N2O3/c1-5(10)9-6(7(11)12)3-2-4-8/h6H,2-4,8H2,1H3,(H,9,10)(H,11,12)/t6-/m0/s1
InChI Key:

JRLGPAXAGHMNOL-LURJTMIESA-N
CAS number:

6205-08-09

Related resources

Literature sources:
- Menni C et al., Metabolomic markers reveal novel pathways of ageing and early development in human populations., International journal of epidemiology, 1111-9, 2013
External links:

HMDB KEGG PubChem ChEBI ChemSpider

Pathway info P = product of S = substrate of

Arginine biosynthesis S P other metabolites from MetaboAge
L-citrulline arginine fumaric acid urea

Metabolic pathways other metabolites from MetaboAge
1,7-dimethyluric acid 1-methylnicotinamide 1-methylxanthine 11,12-dihydroxy-eicosatrienoic acid 4-acetamidobutanoate 4-hydroxybenzoic acid 4-hydroxyphenylacetate 4-methyl-2-oxopentanoate D-glucose D-glucuronate D-mannitol D-mannose D-ribose D-sorbitol D-xylose Dihydroxymandelic acid (DHMA) L-citrulline L-threonine N-acetylneuraminate N-methyl-4-pyridone-3-carboxamide N6-acetyl-lysine NAD+ NADP+ Norepinephrine UDP-acetyl-glucosamine Vanillylmandelic acid (VMA) acetone acetylphenylalanine alpha-tocopherol androstenedione arachidonic acid arginine beta-hydroxyisovalerate beta-tocopherol betaine caffeine campesterol carnosine cholesterol choline choline phosphate citric acid cortisone creatine creatinine dehydroepiandrosterone dimethyl sulfone dimethylamine dimethylglycine fumaric acid gamma-tocopherol glutarate glutathione glycine guanidinoacetic acid gulonic acid homovanillate (HVA) hypoxanthine inosine inositol 1-phosphate kynurenic acid leukotriene E4 linoleic acid myo-inositol niacinamide nicotinic acid normetanephrine oxalic acid p-hydroxyphenylacetic acid paraxanthine phenylglyoxylic acid pregnelone propylene glycol pyridoxic acid pyruvate quinic acid scyllo-inositol sphingosine 1-phosphate taurine theobromine trans-4-hydroxyproline trimethylamine N-oxide tryptamine urate urea uric acid uridine vanillylmandelate (VMA) xanthine

2-Oxocarboxylic acid metabolism S P other metabolites from MetaboAge
4-methyl-2-oxopentanoate citrate citric acid pyruvate

Biosynthesis of amino acids S P other metabolites from MetaboAge
4-methyl-2-oxopentanoate L-citrulline L-threonine arginine citrate citric acid glycine pyruvate

Metabolite sources and localization

Metabolite location:

Human organism, Body part, Human body biofluids, Biofluid tissues, Blood, Plasma, Serum, Saliva, Urine, Organ, Prostate, Tissue, Excreta material
Metabolite source:

Homo sapiens, endogenous metabolite

Age-variations

Linear regression

Method: UHPLC/MS/MS

Sample: serum + plasma

PMID: 23838602

β = 0.006 (y = βx + α)

p-value < 0.05