4-acetamidobutanoate
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Name: 4-acetamidobutanoate
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Description: 4-acetamidobutanoate is a monocarboxylic acid anion that is the conjugate base of 4-acetamidobutanoic acid, arising from deprotonation of the carboxy group. It has a role as a human metabolite. It ...
Overview of age-variations
| Age group comparisons | ||||
|---|---|---|---|---|
| PMID | Age/Age interval, Gender | Value (unit of measurement) | Method | Sample |
| 27374292 | Age [25–35] (median=32), Gender ♀ (Japanese) | 0.848768 (average level of metabolite) | UHPLC-MS/MS Positive mode | serum |
| 27374292 | Age [55–65] (median=60), Gender ♀ (Japanese) | 1.071015 (average level of metabolite) | UHPLC-MS/MS Positive mode | serum |
| 27374292 | Age [25–35] (median=32), Gender ♂ (Japanese) | 0.952045 (average level of metabolite) | UHPLC-MS/MS Positive mode | serum |
| 27374292 | Age [55–64] (median=60), Gender ♂ (Japanese) | 1.140449 (average level of metabolite) | UHPLC-MS/MS Positive mode | serum |
| Linear regression | ||||
|---|---|---|---|---|
| PMID | Age/Age interval, Gender | Value (unit of measurement) | Method | Sample |
| 23838602 | Age [17–85], Gender ⚥ | 0.015 (β) | UHPLC/MS/MS | serum + plasma |
| log2 ratio/log2(FC) | ||||
|---|---|---|---|---|
| PMID | Age/Age interval, Gender | Value (unit of measurement) | Method | Sample |
Summary
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Synonym:N-acetyl-4-aminobutyrate; N-acetyl-γ-aminobutyrate; N4-acetylaminobutanoate; N-acetyl-gamma-aminobutyrate;4-acetamidobutanoate; N-acetyl-4-aminobutanoate; N-acetyl-gamma-aminobutanoate;N-acetyl-4-aminobutyrate
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Chemical Formula:C6H10NO3-
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Exact Mass g/mol:144.0666200
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Systematic name:4-acetamidobutanoate
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SMILES:CC(=O)NCCCC(=O)[O-]
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InChI:InChI=1S/C6H11NO3/c1-5(8)7-4-2-3-6(9)10/h2-4H2,1H3,(H,7,8)(H,9,10)/p-1
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InChI Key:UZTFMUBKZQVKLK-UHFFFAOYSA-M
Related resources
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Literature sources:
- Menni C et al., Metabolomic markers reveal novel pathways of ageing and early development in human populations., International journal of epidemiology, 1111-9, 2013
- Saito K et al., Gender- and Age-Associated Differences in Serum Metabolite Profiles among Japanese Populations., Biological & pharmaceutical bulletin, 1179-86, 2016
Pathway info P = product of S = substrate of
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Arginine and proline metabolism S P other metabolites from MetaboAgearginine creatine creatinine guanidinoacetate guanidinoacetic acid pyruvate trans-4-hydroxyproline urea
Metabolic pathways other metabolites from MetaboAge1,7-dimethyluric acid 1-methylnicotinamide 1-methylxanthine 11,12-dihydroxy-eicosatrienoic acid 4-hydroxybenzoic acid 4-hydroxyphenylacetate 4-methyl-2-oxopentanoate D-glucose D-glucuronate D-mannitol D-mannose D-ribose D-sorbitol D-xylose Dihydroxymandelic acid (DHMA) L-citrulline L-threonine N-acetylneuraminate N-acetylornithine N-methyl-4-pyridone-3-carboxamide N6-acetyl-lysine NAD+ NADP+ Norepinephrine UDP-acetyl-glucosamine Vanillylmandelic acid (VMA) acetone acetylphenylalanine alpha-tocopherol androstenedione arachidonic acid arginine beta-hydroxyisovalerate beta-tocopherol betaine caffeine campesterol carnosine cholesterol choline choline phosphate citric acid cortisone creatine creatinine dehydroepiandrosterone dimethyl sulfone dimethylamine dimethylglycine fumaric acid gamma-tocopherol glutarate glutathione glycine guanidinoacetic acid gulonic acid homovanillate (HVA) hypoxanthine inosine inositol 1-phosphate kynurenic acid leukotriene E4 linoleic acid myo-inositol niacinamide nicotinic acid normetanephrine oxalic acid p-hydroxyphenylacetic acid paraxanthine phenylglyoxylic acid pregnelone propylene glycol pyridoxic acid pyruvate quinic acid scyllo-inositol sphingosine 1-phosphate taurine theobromine trans-4-hydroxyproline trimethylamine N-oxide tryptamine urate urea uric acid uridine vanillylmandelate (VMA) xanthine
Metabolite sources and localization
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Metabolite location:Human organism, Body part, Human body biofluids, Biofluid tissues, Blood, Plasma, Serum, Tissue
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Metabolite source:Homo sapiens, endogenous metabolite
Age-variations
Linear regression
Method: UHPLC/MS/MS
Sample: serum + plasma
β = 0.015
(y = βx + α)
p-value < 0.05