paraxanthine
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Name: paraxanthine
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Description: 1,7-dimethylxanthine (paraxanthine) is the preferential path of caffeine metabolism in humans. Paraxanthine is a dimethylxanthine compound structurally related to caffeine. Like caffeine, paraxanth...
Overview of age-variations
| Age group comparisons | ||||
|---|---|---|---|---|
| PMID | Age/Age interval, Gender | Value (unit of measurement) | Method | Sample |
| 18384253 | Age 24.5 ± 3, Gender ⚥ | 0.32 (mean value of the compound area) | LC-MS; GC-MS | plasma |
| 18384253 | Age 40.8 ± 5.6, Gender ⚥ | 0.69 (mean value of the compound area) | LC-MS; GC-MS | plasma |
| 18384253 | Age 55.6 ± 3.7, Gender ⚥ | 0.81 (mean value of the compound area) | LC-MS; GC-MS | plasma |
| Linear regression | ||||
|---|---|---|---|---|
| PMID | Age/Age interval, Gender | Value (unit of measurement) | Method | Sample |
| log2 ratio/log2(FC) | ||||
|---|---|---|---|---|
| PMID | Age/Age interval, Gender | Value (unit of measurement) | Method | Sample |
| 26088811 | Age 40.9 ± 10.3, Gender ⚥ | 3.0 (log2 ratio) | UHPLC positive mode | urine |
Summary
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Synonym:1,7-dimethylxanthine
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Chemical Formula:C7H8N4O2
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Exact Mass g/mol:180.0650000
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Systematic name:1,7-dimethyl-3H-purine-2,6-dione
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SMILES:CN1C=NC2=C1C(=O)N(C(=O)N2)C
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InChI:InChI=1S/C7H8N4O2/c1-10-3-8-5-4(10)6(12)11(2)7(13)9-5/h3H,1-2H3,(H,9,13)
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InChI Key:QUNWUDVFRNGTCO-UHFFFAOYSA-N
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CAS number:611-59-6
Related resources
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Literature sources:
- Lawton KA et al., Analysis of the adult human plasma metabolome., Pharmacogenomics, 383-97, 2008
- Thévenot EA et al., Analysis of the Human Adult Urinary Metabolome Variations with Age, Body Mass Index, and Gender by Implementing a Comprehensive Workflow for Univariate and OPLS Statistical Analyses., Journal of proteome research, 3322-35, 2015
Pathway info P = product of S = substrate of
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Metabolic pathways other metabolites from MetaboAge1,7-dimethyluric acid 1-methylnicotinamide 1-methylxanthine 11,12-dihydroxy-eicosatrienoic acid 4-acetamidobutanoate 4-hydroxybenzoic acid 4-hydroxyphenylacetate 4-methyl-2-oxopentanoate D-glucose D-glucuronate D-mannitol D-mannose D-ribose D-sorbitol D-xylose Dihydroxymandelic acid (DHMA) L-citrulline L-threonine N-acetylneuraminate N-acetylornithine N-methyl-4-pyridone-3-carboxamide N6-acetyl-lysine NAD+ NADP+ Norepinephrine UDP-acetyl-glucosamine Vanillylmandelic acid (VMA) acetone acetylphenylalanine alpha-tocopherol androstenedione arachidonic acid arginine beta-hydroxyisovalerate beta-tocopherol betaine caffeine campesterol carnosine cholesterol choline choline phosphate citric acid cortisone creatine creatinine dehydroepiandrosterone dimethyl sulfone dimethylamine dimethylglycine fumaric acid gamma-tocopherol glutarate glutathione glycine guanidinoacetic acid gulonic acid homovanillate (HVA) hypoxanthine inosine inositol 1-phosphate kynurenic acid leukotriene E4 linoleic acid myo-inositol niacinamide nicotinic acid normetanephrine oxalic acid p-hydroxyphenylacetic acid phenylglyoxylic acid pregnelone propylene glycol pyridoxic acid pyruvate quinic acid scyllo-inositol sphingosine 1-phosphate taurine theobromine trans-4-hydroxyproline trimethylamine N-oxide tryptamine urate urea uric acid uridine vanillylmandelate (VMA) xanthine
Metabolite sources and localization
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Metabolite location:Human organism, Body part, Human body biofluids, Biofluid tissues, Blood, Plasma, Cerebrospinal fluid, Saliva, Urine, Organ, Kidney, Liver, Prostate, Tissue, Cellular (general class), Subcellular, Cytoplasm, Excreta material, Feces
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Metabolite source:Homo sapiens, exogenous metabolite