D-glucuronate

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  • Name: D-glucuronate
  • Description: D-glucuronate is a reducing acidic sugar that often forms a hexapyranose ring structure. It is common in carbohydrate chains of proteoglycans and is part of mucous animal secretions (such as saliva... ), cell glycocalyx and intercellular matrix. The hexapyranosic form β-D-glucuronate is found in the glycosaminoglycans chondroitin sulfate, dermatan sulfate, heparin, heparan sulfate and hyaluronan. It results from the deprotonation of the carboxyl group of D-glucuronic acid; it is the major species at pH 7.3. (CHEBI:142686)
Overview of age-variations
Age group comparisons
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
27374292 Age [25–35] (median=32), Gender ♀ (Japanese) 0.834921 (average level of metabolite) UHPLC-MS/MS HILIC serum
27374292 Age [55–65] (median=60), Gender ♀ (Japanese) 1.036715 (average level of metabolite) UHPLC-MS/MS HILIC serum
Linear regression
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
log2 ratio/log2(FC)
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
Summary
  • Synonym:
    aldehydo-D-glucuronate; (2S,3S,4S,5R)-3,4,5,6-tetrahydroxytetrahydropyran-2-carboxylate;D-glucopyranuronate; (2S,3S,4S,5R)-3,4,5,6-tetrahydroxytetrahydro-2H-pyran-2-carboxylate; (2S,3S,4S,5R)-2,3,4,5-tetrahydroxy-6-oxocaproate
  • Chemical Formula:
    C6H9O7-
  • Exact Mass g/mol:
    193.0348300
  • Systematic name:
    (2S,3S,4S,5R)-3,4,5,6-tetrahydroxyoxane-2-carboxylate; (2S,3S,4S,5R)-2,3,4,5-tetrahydroxy-6-oxohexanoate
  • SMILES:
    OC1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C([O-])=O
  • InChI:
    InChI=1S/C6H10O7/c7-1-2(8)4(5(10)11)13-6(12)3(1)9/h1-4,6-9,12H,(H,10,11)/p-1/t1-,2-,3+,4-,6?/m0/s1
  • InChI Key:
    AEMOLEFTQBMNLQ-AQKNRBDQSA-M
Related resources
Pathway info P = product of S = substrate of
Metabolite sources and localization
  • Metabolite location:
    Human organism, Body part, Human body biofluids, Biofluid tissues, Blood, Serum, Tissue
  • Metabolite source:
    Homo sapiens, endogenous metabolite
Age-variations
Age group comparisons
Method: UHPLC-MS/MS HILIC
Sample: serum
PubMed PMID: 27374292
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