ribitol

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  • Name: ribitol
  • Description: Ribitol is a pentitol (five-carbon sugar alcohol, polyol) having meso-configuration, being derived from ribose by reduction of the carbonyl group. It occurs naturally in the plant Adonis vernalis. ... It has a role as a Daphnia magna metabolite, a plant metabolite and a human metabolite. It is a metabolic end product formed by the reduction of ribose in human fibroblasts and erythrocytes. Export of ribitol across the cell membrane indicates that it can be cleared from the body without metabolic conversion (PMID 15234337). Several inborn errors of metabolism with abnormal polyol concentrations in body fluids are known to date, such as ribose-5-phosphate isomerase deficiency. Most of these defects can be diagnosed by the assessment of urinary concentrations of polyols (PMID 16435188). Ribitol is normally absent in breast milk (PMID 16456418; CHEBI:15963)
Overview of age-variations
Age group comparisons
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
27374292 Age [25–35] (median=32), Gender ♀ (Japanese) 0.957662 (average level of metabolite) UHPLC-MS/MS HILIC serum
27374292 Age [55–65] (median=60), Gender ♀ (Japanese) 1.071703 (average level of metabolite) UHPLC-MS/MS HILIC serum
27374292 Age [25–35] (median=32), Gender ♂ (Japanese) 0.906226 (average level of metabolite) UHPLC-MS/MS HILIC serum
27374292 Age [55–64] (median=60), Gender ♂ (Japanese) 1.151226 (average level of metabolite) UHPLC-MS/MS HILIC serum
Linear regression
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
log2 ratio/log2(FC)
PMID Age/Age interval, Gender Value (unit of measurement) Method Sample
Summary
  • Synonym:
    meso-ribitol; (2R,3s,4S)-1,2,3,4,5-pentanepentol;adonitol
  • Chemical Formula:
    C5H12O5
  • Exact Mass g/mol:
    152.0684700
  • Systematic name:
    (2R,3s,4S)-pentane-1,2,3,4,5-pentol
  • SMILES:
    OC[C@H](O)[C@H](O)[C@H](O)CO
  • InChI:
    InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5-
  • InChI Key:
    HEBKCHPVOIAQTA-ZXFHETKHSA-N
  • CAS number:
    488-81-3
Related resources
Pathway info P = product of S = substrate of
Metabolite sources and localization
  • Metabolite location:
    Human organism, Body part, Extracellular, Human body biofluids, Biofluid tissues, Blood, Serum, Cerebrospinal fluid, Urine, Organ, Prostate, Tissue, Cellular (general class), Subcellular, Cytoplasm, Excreta material, Feces
  • Metabolite source:
    Homo sapiens, endogenous metabolite
Age-variations
Age group comparisons
Method: UHPLC-MS/MS HILIC
Sample: serum
PubMed PMID: 27374292
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